The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

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第一作者： Wenjing,Su

第一单位： Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

作者： Wenjing,Su ^[1] ; Hyun Ho,Han ^[2] ; Yan,Wang ^[3] ; Boyu,Zhang ^[3] ; Bing,Zhou ^[4] ; Yuanming,Cheng ^[1] ; Alekya,Rumandla ^[3] ; Sreeharsha,Gurrapu ^[3] ; Goutam,Chakraborty ^[5] ; Jie,Su ^[6] ; Guangli,Yang ^[7] ; Xin,Liang ^[8] ; Guocan,Wang ^[8] ; Neal,Rosen ^[1] ; Howard I,Scher ^[9] ; Ouathek,Ouerfelli ^[7] ; Filippo G,Giancotti ^[10]

作者单位： Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. ^[1] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Unit 1906, PO Box 301429, Houston, TX 77054/77030-1429, USA; Department of Urology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. ^[2] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Unit 1906, PO Box 301429, Houston, TX 77054/77030-1429, USA. ^[3] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. ^[4] Department of Medicine, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. ^[5] Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. ^[6] Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA. ^[7] Department of Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. ^[8] Genitourinary Oncology Service, Department of Medicine, MSKCC, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. ^[9] Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Unit 1906, PO Box 301429, Houston, TX 77054/77030-1429, USA; Department of Genitourinary Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: fggiancotti@mdanderson.org. ^[10]

关键词 MDSCs Tregs angiogenesis combination therapy epigenetics immune evasion immune microenvironment metastasis preclinical compound stemness