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Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health.

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第一作者： Nicolas,Delcourt

第一单位： Poison Control Centre, Toulouse-Purpan University Hospital and Toulouse NeuroImaging Centre (ToNIC), INSERM1214, Toulouse-Purpan University Hospital, 31059 Toulouse, France.

作者： Nicolas,Delcourt ^[1] ; Emmeline,Lagrange ^[2] ; Eric,Abadie ^[3] ; Valérie,Fessard ^[4] ; Jean-Marc,Frémy ^[5] ; Jean-Paul,Vernoux ^[6] ; Marie-Bénédicte,Peyrat ^[7] ; Thomas,Maignien ^[7] ; Nathalie,Arnich ^[7] ; Jordi,Molgó ^[8] ; César,Mattei ^[9]

作者单位： Poison Control Centre, Toulouse-Purpan University Hospital and Toulouse NeuroImaging Centre (ToNIC), INSERM1214, Toulouse-Purpan University Hospital, 31059 Toulouse, France. ^[1] Department of Neurology, Reference Center of Neuromuscular Disease, Grenoble University Hospital, 38000 Grenoble, France. ^[2] Laboratoire Environnement Ressources du Languedoc-Roussillon, Centre for Marine Biodiversity, Exploitation and Conservation (MARBEC), IRD, Institut Français de Recherche pour l'Exploitation de la Mer (Ifremer), CNRS, Université de Montpellier, CS30171, 34200 Sete Cedex 03, France. ^[3] Toxicology of Contaminants Unit, ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 35306 Fougères, France. ^[4] Retired from ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France. ^[5] Research Unit EA 4651 Aliments Bioprocédés Toxicologie Environnements (ABTE), Normandie University, 14000 Caen, France. ^[6] Risk Assessment Department, ANSES-French Agency for Food, Environmental and Occupational Health & Safety, 94701 Maisons-Alfort, France. ^[7] Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) Saclay, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France. jordi.molgo@cea.fr.;Institut des Neurosciences Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), UMR 9197 CNRS/Université Paris-Sud, F-91198 Gif-sur-Yvette, France. jordi.molgo@cea.fr. ^[8] Mitochondrial and Cardiovascular Pathophysiology (MITOVASC), Cardiovascular Mechanotransduction, UMR CNRS 6015, INSERM U1083, Angers University, 49045 Angers, France. cesar.mattei@univ-angers.fr. ^[9]

关键词 Vulcanodinium rugosum acute neurotoxicity cyclic imines human intoxication myasthenia gravis nicotinic acetylcholine receptors pinnatoxins