Accelerating bioprocess development by analysis of all available data: A USP case study.

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作者： Diego A,Suarez-Zuluaga ^[1] ; Daniel,Borchert ^[2] ; Nicole N,Driessen ^[1] ; Wilfried A M,Bakker ^[1] ; Yvonne E,Thomassen ^[3]

作者单位： Intravacc, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, the Netherlands. ^[1] Exputec GmbH, Mariahilferstraße 147/2/2D, 1150 Vienna, Austria; Vienna University of Technology, Research Area Biochemical Engineering, Gumpendorferstrasse 1a, 1060 Vienna, Austria. ^[2] Intravacc, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, the Netherlands. Electronic address: yvonne.thomassen@intravacc.nl. ^[3]

关键词 Cause and effect analysis Comprehensive data gathering Design of experiments Inactivated poliovirus vaccine Multivariate data analysis

主题词动物(Animals);生物反应器(Bioreactors);最小二乘法分析(Least-Squares Analysis);脊髓灰质炎病毒(Poliovirus);脊髓灰质炎病毒疫苗, 灭活(Poliovirus Vaccine, Inactivated);主成分分析(Principal Component Analysis);Vero细胞(Vero Cells)

DOI 10.1016/j.vaccine.2019.07.026

PMID 31337593

发布时间 2020-09-29

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