Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice.-论文-万方医学网

作者： Agostina,Carestia ^[1] ; Hebe A,Mena ^[2] ; Cinthia M,Olexen ^[2] ; Juan M,Ortiz Wilczyñski ^[2] ; Soledad,Negrotto ^[2] ; Andrea E,Errasti ^[3] ; Ricardo M,Gómez ^[4] ; Craig N,Jenne ^[5] ; Eugenio A,Carrera Silva ^[6] ; Mirta,Schattner ^[7]

作者单位： Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, IMEX-CONICET-National Academy of Medicine, Buenos Aires, Argentina; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada. ^[1] Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, IMEX-CONICET-National Academy of Medicine, Buenos Aires, Argentina. ^[2] Institute of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina. ^[3] Institute of Biotechnology and Molecular Biology, CCT-La Plata, CONICET-UNLP, La Plata, Argentina. ^[4] Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada. ^[5] Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, IMEX-CONICET-National Academy of Medicine, Buenos Aires, Argentina. Electronic address: carrerasilva@yahoo.com.ar. ^[6] Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, IMEX-CONICET-National Academy of Medicine, Buenos Aires, Argentina. Electronic address: mschattner@hotmail.com. ^[7]

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);血小板(Blood Platelets);细胞间通讯(Cell Communication);细胞极性(Cell Polarity);细胞因子类(Cytokines);炎症(Inflammation);炎症介导素类(Inflammation Mediators);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);单核细胞(Monocytes);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);表型(Phenotype);血小板糖蛋白GPⅠb-Ⅸ复合物(Platelet Glycoprotein GPIb-IX Complex);血小板输注(Platelet Transfusion);脓毒症(Sepsis);休克, 脓毒性(Shock, Septic);存活率分析(Survival Analysis)

DOI 10.1016/j.celrep.2019.06.062

PMID 31340152

发布时间 2020-08-24

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Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice.

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Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice.

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