Identification of evolutionary and kinetic drivers of NAD-dependent signaling.

导出 OA

翻译打印收藏纠错

作者： Mathias,Bockwoldt ^[1] ; Dorothée,Houry ^[2] ; Marc,Niere ^[3] ; Toni I,Gossmann ^[4] ; Ines,Reinartz ^[5] ; Alexander,Schug ^[6] ; Mathias,Ziegler ^[7] ; Ines,Heiland ^[8]

作者单位： Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9017 Tromsø, Norway. ^[1] Department of Biological Sciences, University of Bergen, 5006 Bergen, Norway. ^[2] Department of Biomedicine, University of Bergen, 5009 Bergen, Norway. ^[3] Department of Animal and Plant Sciences, Western Bank, University of Sheffield, S10 2TN Sheffield, United Kingdom. ^[4] Department of Animal Behaviour, Bielefeld University, 33501 Bielefeld, Germany. ^[5] Department of Physics, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany. ^[6] Steinbuch Centre for Computing, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany. ^[7] John von Neumann Institute for Computing, Jülich Supercomputing Centre, Forschungszentrum Jülich, 52425 Jülich, Germany. ^[8] Department of Arctic and Marine Biology, UiT The Arctic University of Norway, 9017 Tromsø, Norway; ines.heiland@uit.no. ^[9]

关键词 NAD pathway dynamics and evolution NAD-dependent signaling and biosynthesis mathematical modeling nicotinamide N-methyltransferase (NNMT)nicotinamide phosphoribosyltransferase (NamPT)