Identification of an emphysema-associated genetic variant near <i>TGFB2</i> with regulatory effects in lung fibroblasts.

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第一作者： Margaret M,Parker

第一单位： Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, United States.

作者： Margaret M,Parker ^[1] ; Yuan,Hao ^[1] ; Feng,Guo ^[1] ; Betty,Pham ^[1] ; Robert,Chase ^[1] ; John,Platig ^[1] ; Michael H,Cho ^[1] ; Craig P,Hersh ^[2] ; Victor J,Thannickal ^[1] ; James,Crapo ^[2] ; George,Washko ^[3] ; Scott H,Randell ^[4] ; Edwin K,Silverman ^[2] ; Raúl,San José Estépar ^[5] ; Xiaobo,Zhou ^[1] ; Peter J,Castaldi ^[2]

作者单位： Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, United States. ^[1] Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, United States. ^[2] Division of Pulmonary, Allergy and Critical Care, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, United States. ^[3] Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, United States. ^[4] Marsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, United States. ^[5] Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Boston, United States. ^[6] Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, United States. ^[7]

关键词 COPD TGF-beta signaling bioinformatics emphysema genetics genome-wide association study genomics human human biology medicine transcriptomics