首页> Acta neuropathologica communications> Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

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第一作者： Suman,De

第一单位： Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.;UK Dementia Research Institute at University of Cambridge, Cambridge, CB2 0XY, UK.

作者： Suman,De ^[1] ; Daniel R,Whiten ^[2] ; Francesco S,Ruggeri ^[3] ; Craig,Hughes ^[4] ; Margarida,Rodrigues ^[2] ; Dimitrios I,Sideris ^[2] ; Christopher G,Taylor ^[2] ; Francesco A,Aprile ^[3] ; Serge,Muyldermans ^[5] ; Tuomas P J,Knowles ^[3] ; Michele,Vendruscolo ^[3] ; Clare,Bryant ^[4] ; Kaj,Blennow ^[6] ; Ingmar,Skoog ^[7] ; Silke,Kern ^[7] ; Henrik,Zetterberg ^[8] ; David,Klenerman ^[9]

作者单位： Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.;UK Dementia Research Institute at University of Cambridge, Cambridge, CB2 0XY, UK. ^[1] Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. ^[2] Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.;Centre for Misfolding Diseases, University of Cambridge, Cambridge, CB2 1EW, UK. ^[3] Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK. ^[4] Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium. ^[5] Clinical Neurochemistry Laboratory, Unit of Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. ^[6] Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. ^[7] Clinical Neurochemistry Laboratory, Unit of Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden.;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, UK.;UK Dementia Research Institute at University College London, London, UK. ^[8] Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. dk10012@cam.ac.uk.;UK Dementia Research Institute at University of Cambridge, Cambridge, CB2 0XY, UK. dk10012@cam.ac.uk. ^[9]

关键词 Alzheimer’s disease Cerebrospinal fluid Disease mechanism Mild cognitive impairment Protein aggregation Structure-function relation Super-resolution imaging