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Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture.

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第一作者： Caroline,Halloin

第一单位： Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Cluster of Excellence, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

作者： Caroline,Halloin ^[1] ; Kristin,Schwanke ^[1] ; Wiebke,Löbel ^[1] ; Annika,Franke ^[1] ; Monika,Szepes ^[1] ; Santoshi,Biswanath ^[1] ; Stephanie,Wunderlich ^[1] ; Sylvia,Merkert ^[1] ; Natalie,Weber ^[2] ; Felix,Osten ^[2] ; Jeanne,de la Roche ^[3] ; Felix,Polten ^[4] ; Kai,Christoph Wollert ^[4] ; Theresia,Kraft ^[2] ; Martin,Fischer ^[3] ; Ulrich,Martin ^[1] ; Ina,Gruh ^[1] ; Henning,Kempf ^[5] ; Robert,Zweigerdt ^[6]

作者单位： Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Cluster of Excellence, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. ^[1] Institute of Molecular and Cell Physiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. ^[2] Institute for Neurophysiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. ^[3] Division of Molecular and Translational Cardiology and Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. ^[4] Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Cluster of Excellence, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. Electronic address: henningkempf@outlook.com. ^[5] Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic-, Transplantation and Vascular Surgery, REBIRTH-Cluster of Excellence, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. Electronic address: zweigerdt.robert@mh-hannover.de. ^[6]

关键词 ROR1 WNT cardiac differentiation cardiomyocyte chemically defined process human pluripotent stem cells process development stirred tank bioreactor suspension culture upscaling