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The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

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第一作者： Rosa Angela,Cardone

第一单位： Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy.

作者： Rosa Angela,Cardone ^[1] ; Khalid Omer,Alfarouk ^[2] ; Robert L,Elliott ^[3] ; Saad Saaed,Alqahtani ^[4] ; Samrein B M,Ahmed ^[5] ; Ahmed N,Aljarbou ^[6] ; Maria Raffaella,Greco ^[1] ; Stefania,Cannone ^[1] ; Stephan Joel,Reshkin ^[7]

作者单位： Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy. ^[1] Alfarouk Biomedical Research LLC, Tampa, FL 33617, USA. Alfarouk@Hala-Alfarouk.org.;Hala Alfarouk Cancer Center, Khartoum 11112, Sudan. Alfarouk@Hala-Alfarouk.org.;American Biosciences Inc., New York, NY 10913, USA. Alfarouk@Hala-Alfarouk.org. ^[2] The Sallie A. Burdine Breast Foundation, Baton Rouge, LA 70806, USA.;The Elliott-Elliott-Baucom Breast Cancer Research and Treatment Center, Baton Rouge, LA 70806, USA. ^[3] Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia. ^[4] College of Medicine, University of Sharjah, Sharjah, UAE. ^[5] College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia. ^[6] Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari, 90126 Bari, Italy. khaliomer@gmail.com. ^[7]

关键词 Na+/H+ exchanger pH and Warburg metabolism pH and cancer proton transport in cancer tumor metabolic microenvironment