Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14.

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作者： Alexandra,Surcel ^[1] ; Eric S,Schiffhauer ^[2] ; Dustin G,Thomas ^[2] ; Qingfeng,Zhu ^[3] ; Kathleen T,DiNapoli ^[2] ; Maik,Herbig ^[4] ; Oliver,Otto ^[5] ; Hoku,West-Foyle ^[5] ; Angela,Jacobi ^[2] ; Martin,Kräter ^[5] ; Katarzyna,Plak ^[5] ; Jochen,Guck ^[5] ; Elizabeth M,Jaffee ^[5] ; Pablo A,Iglesias ^[6] ; Robert A,Anders ^[2] ; Douglas N,Robinson ^[4]

作者单位： Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland. dnr@jhmi.edu asurcel1@jhmi.edu. ^[1] Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland. ^[2] Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. ^[3] Department of Electrical and Computer Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, Maryland. ^[4] Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität Dresden, Dresden, Germany. ^[5] Department of Oncology, Sidney Kimmel Cancer Center at Johns Hopkins, The Skip Viragh Pancreatic Cancer Center, and the Bloomberg Kimmel Institute, Johns Hopkins University, Baltimore, Maryland. ^[6] Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. ^[7] Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. ^[8]