Antisense oligonucleotides extend survival of prion-infected mice.

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第一作者： Gregory J,Raymond

第一单位： Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana, USA.

作者： Gregory J,Raymond ^[1] ; Hien Tran,Zhao ^[2] ; Brent,Race ^[1] ; Lynne D,Raymond ^[1] ; Katie,Williams ^[1] ; Eric E,Swayze ^[2] ; Samantha,Graffam ^[3] ; Jason,Le ^[3] ; Tyler,Caron ^[3] ; Jacquelyn,Stathopoulos ^[3] ; Rhonda,O'Keefe ^[3] ; Lori L,Lubke ^[1] ; Andrew G,Reidenbach ^[3] ; Allison,Kraus ^[1] ; Stuart L,Schreiber ^[3] ; Curt,Mazur ^[2] ; Deborah E,Cabin ^[4] ; Jeffrey B,Carroll ^[5] ; Eric Vallabh,Minikel ^[6] ; Holly,Kordasiewicz ^[2] ; Byron,Caughey ^[1] ; Sonia M,Vallabh ^[6]

作者单位： Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana, USA. ^[1] Ionis Pharmaceuticals Inc., Carlsbad, California, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. ^[3] McLaughlin Research Institute, Great Falls, Montana, USA. ^[4] Western Washington University, Bellingham, Washington, USA. ^[5] Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana, USA.;Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.;Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts, USA.;Prion Alliance, Cambridge, Massachusetts, USA. ^[6]

关键词 Gene therapy Neurodegeneration Neuroscience Prions Therapeutics

主题词动物(Animals);脑(Brain);疾病模型, 动物(Disease Models, Animal);药物发现(Drug Discovery);女(雌)性(Female);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);寡核苷酸类, 反义(Oligonucleotides, Antisense);朊病毒病(Prion Diseases);存活率(Survival Rate)

DOI 10.1172/jci.insight.131175

PMID 31361599

发布时间 2020-09-21

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Antisense oligonucleotides extend survival of prion-infected mice.

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Antisense oligonucleotides extend survival of prion-infected mice.

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