Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).

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第一作者： Stephanie,Chin

第一单位： Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G0A4, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON M5G0A4, Canada.

作者： Stephanie,Chin ^[1] ; Mohabir,Ramjeesingh ^[2] ; Maurita,Hung ^[3] ; June,Ereño-Oreba ^[2] ; Hong,Cui ^[2] ; Onofrio,Laselva ^[3] ; Jean-Philippe,Julien ^[4] ; Christine E,Bear ^[5]

作者单位： Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G0A4, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON M5G0A4, Canada. ^[1] Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G0A4, Canada. ^[2] Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G0A4, Canada.;Department of Physiology, University of Toronto, Toronto, ON M5G0A4, Canada. ^[3] Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G0A4, Canada.;Department of Biochemistry, University of Toronto, Toronto, ON M5G0A4, Canada.;Department of Immunology, University of Toronto, Toronto, ON M5G0A4, Canada. ^[4] Programme in Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto, ON M5G0A4, Canada. bear@sickkids.ca.;Department of Biochemistry, University of Toronto, Toronto, ON M5G0A4, Canada. bear@sickkids.ca.;Department of Physiology, University of Toronto, Toronto, ON M5G0A4, Canada. bear@sickkids.ca. ^[5]

关键词 amphipol:A8-35 catalytic activity functional reconstitution intrinsic anion channel activity membrane protein purification proteoliposomal flux

主题词腺苷三磷酸(Adenosine Triphosphate);胆固醇(Cholesterol);囊性纤维化跨膜传导调节因子(Cystic Fibrosis Transmembrane Conductance Regulator);HEK293细胞(HEK293 Cells);人类(Humans);微胶粒(Micelles);磷脂类(Phospholipids);磷酰化(Phosphorylation);聚合物(Polymers);丙胺类(Propylamines)

DOI 10.3390/cells8080804

PMID 31370288

发布时间 2020-04-16

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2019年8卷8期

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Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).

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Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).

Cells

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Cells

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