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首页> European journal of medicinal chemistry> Structure-activity relationships of new Organotin(IV) anticancer agents and their cytotoxicity profile on HL-60, MCF-7 and HeLa human cancer cell lines.

Structure-activity relationships of new Organotin(IV) anticancer agents and their cytotoxicity profile on HL-60, MCF-7 and HeLa human cancer cell lines.

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作者： Hussain,Ullah ^[1] ; Viola,Previtali ^[2] ; Helene B,Mihigo ^[2] ; Brendan,Twamley ^[3] ; Muhammad Khawar,Rauf ^[4] ; Fatima,Javed ^[4] ; Amir,Waseem ^[5] ; Robert J,Baker ^[6] ; Isabel,Rozas ^[7]

作者单位： Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan; School of Chemistry, Trinity College Dublin, Dublin 2, Ireland. ^[1] School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. ^[2] School of Chemistry, Trinity College Dublin, Dublin 2, Ireland. ^[3] Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan. ^[4] Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address: amir@qau.edu.pk. ^[5] School of Chemistry, Trinity College Dublin, Dublin 2, Ireland. Electronic address: bakerrj@tcd.ie. ^[6] School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. Electronic address: rozasi@tcd.ie. ^[7]

关键词 Anticancer agents Apoptosis Cell growth inhibition HL-60 HeLa MCF-7 Organotin(IV)complexes Structure-activity relationships

主题词抗肿瘤药(Antineoplastic Agents);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);HL-60细胞(HL-60 Cells);人类(Humans);分子结构(Molecular Structure);有机锡化合物(Organotin Compounds);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2019.07.047

PMID 31374420

发布时间 2019-12-30

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European journal of medicinal chemistry

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