Pegvaliase: Immunological profile and recommendations for the clinical management of hypersensitivity reactions in patients with phenylketonuria treated with this enzyme substitution therapy.

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作者： Oliver,Hausmann ^[1] ; Mohamed,Daha ^[2] ; Nicola,Longo ^[3] ; Edward,Knol ^[4] ; Ingo,Müller ^[5] ; Hope,Northrup ^[6] ; Knut,Brockow ^[7]

作者单位： Adverse Drug Reactions, Analysis & Consulting (ADR-AC) GmbH, Bern, and Research Affiliate, Department of Rheumatology, Immunology and Allergology Inselspital, University of Bern, Switzerland. ^[1] Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. ^[2] Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. ^[3] Department of Immunology and Dermatology, Department of Allergology, University Medical Center Utrecht, Utrecht, the Netherlands. ^[4] Division of Pediatric Stem Cell Transplantation and Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ^[5] Department of Pediatrics, The McGovern Medical School, Houston, TX, USA. ^[6] Department of Dermatology and Allergy, School of Medicine Technical University of Munich, Munich, Germany. Electronic address: knut.brockow@tum.de. ^[7]

关键词 Complement Immune complex Pegvaliase Phenylalanine ammonia lyase Phenylketonuria Type III hypersensitivity

主题词抗体(Antibodies);临床试验, Ⅲ期(主题)(Clinical Trials, Phase III as Topic);疾病管理(Disease Management);酶替代疗法(Enzyme Replacement Therapy);人类(Humans);超敏反应(Hypersensitivity);苯丙氨酸(Phenylalanine);苯丙氨酸氨裂合酶(Phenylalanine Ammonia-Lyase);苯丙酮尿症(Phenylketonurias);重组蛋白质类(Recombinant Proteins);时间因素(Time Factors)

DOI 10.1016/j.ymgme.2019.05.006

PMID 31375398

发布时间 2020-04-30

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Molecular genetics and metabolism

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Pegvaliase: Immunological profile and recommendations for the clinical management of hypersensitivity reactions in patients with phenylketonuria treated with this enzyme substitution therapy.

Molecular genetics and metabolism

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Molecular genetics and metabolism

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Pegvaliase: Immunological profile and recommendations for the clinical management of hypersensitivity reactions in patients with phenylketonuria treated with this enzyme substitution therapy.

Molecular genetics and metabolism

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Molecular genetics and metabolism

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