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Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.

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第一作者： Mohammad,Rashidian

第一单位： Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115.;Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215.

作者： Mohammad,Rashidian ^[1] ; Martin W,LaFleur ^[2] ; Vincent L,Verschoor ^[3] ; Anushka,Dongre ^[4] ; Yun,Zhang ^[4] ; Thao H,Nguyen ^[2] ; Stephen,Kolifrath ^[3] ; Amir R,Aref ^[5] ; Christie J,Lau ^[5] ; Cloud P,Paweletz ^[5] ; Xia,Bu ^[6] ; Gordon J,Freeman ^[6] ; M Inmaculada,Barrasa ^[4] ; Robert A,Weinberg ^[7] ; Arlene H,Sharpe ^[8] ; Hidde L,Ploegh ^[9]

作者单位： Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115.;Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215. ^[1] Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.;Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. ^[2] Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115. ^[3] Whitehead Institute for Biomedical Research, Cambridge, MA 02142. ^[4] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.;Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215. ^[5] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215. ^[6] Whitehead Institute for Biomedical Research, Cambridge, MA 02142.;Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139. ^[7] Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.;Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.;Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. ^[8] Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; hidde.ploegh@childrens.harvard.edu.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115. ^[9]

关键词 PET imaging checkpoint blockade nanobodies single-cell RNA sequencing tumor immune microenvironment