Applications of amide isosteres in medicinal chemistry.

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第一作者： Shaoyi,Sun

第一单位： Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. Electronic address: ssun@xenon-pharma.com.

作者： Shaoyi,Sun ^[1] ; Qi,Jia ^[2] ; Zaihui,Zhang ^[3]

作者单位： Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. Electronic address: ssun@xenon-pharma.com. ^[1] Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. ^[2] Signalchem Lifesciences Corp., 110-13210, Vanier Place, Richmond, BC V6V 2J2, Canada. ^[3]

关键词 3-Aminooxetane Amide isostere Boronic acid Fluoroalkene Heterocycle Transition-state mimic Trifluoroethylamine

主题词酰胺类(Amides);化学, 药物(Chemistry, Pharmaceutical);药物设计(Drug Design);分子结构(Molecular Structure)

DOI 10.1016/j.bmcl.2019.07.033

PMID 31377035

发布时间 2020-10-15

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