Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.-论文-万方医学网

作者： Dequina A,Nicholas ^[1] ; Elizabeth A,Proctor ^[2] ; Madhur,Agrawal ^[3] ; Anna C,Belkina ^[4] ; Stephen C,Van Nostrand ^[2] ; Leena,Panneerseelan-Bharath ^[1] ; Albert R,Jones ^[1] ; Forum,Raval ^[1] ; Blanche C,Ip ^[1] ; Min,Zhu ^[1] ; Jose M,Cacicedo ^[5] ; Chloe,Habib ^[1] ; Nestor,Sainz-Rueda ^[5] ; Leah,Persky ^[1] ; Patrick G,Sullivan ^[6] ; Barbara E,Corkey ^[5] ; Caroline M,Apovian ^[5] ; Philip A,Kern ^[7] ; Douglas A,Lauffenburger ^[8] ; Barbara S,Nikolajczyk ^[9]

作者单位： Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA. ^[1] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. ^[2] Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA. ^[3] Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA. ^[4] Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. ^[5] Department of Neuroscience, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA. ^[6] Department of Medicine, University of Kentucky, Lexington, KY 40536, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. ^[7] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: lauffen@mit.edu. ^[8] Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address: barb.nik@uky.edu. ^[9]

主题词成年人(Adult);老年人(Aged);肉碱(Carnitine);肉碱O-软脂酰转移酶(Carnitine O-Palmitoyltransferase);细胞, 培养的(Cells, Cultured);横断面研究(Cross-Sectional Studies);细胞因子类(Cytokines);糖尿病, 2型(Diabetes Mellitus, Type 2);脂肪酸类(Fatty Acids);女(雌)性(Female);基因敲低技术(Gene Knockdown Techniques);糖酵解(Glycolysis);人类(Humans);炎症(Inflammation);淋巴细胞活化(Lymphocyte Activation);男(雄)性(Male);膜转运蛋白质类(Membrane Transport Proteins);中年人(Middle Aged);肥胖症(Obesity);氧化还原(Oxidation-Reduction);Th17细胞(Th17 Cells);转染(Transfection);青年人(Young Adult)

DOI 10.1016/j.cmet.2019.07.004

PMID 31378464

发布时间 2021-10-15

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Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell metabolism

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Cell metabolism

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Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell metabolism

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Cell metabolism

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