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首页> Cell death & disease> miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease.

miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease.

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作者： Yong-Bo,Hu ^[1] ; Yong-Fang,Zhang ^[2] ; Hao,Wang ^[2] ; Ru-Jing,Ren ^[3] ; Hai-Lun,Cui ^[1] ; Wan-Ying,Huang ^[1] ; Qi,Cheng ^[2] ; Hong-Zhuan,Chen ^[4] ; Gang,Wang ^[2]

作者单位： Department of Neurology & Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. ^[1] Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. ^[2] Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. angela_wanghao@hotmail.com. ^[3] School of Public health Shanghai Jiao Tong university, 200025, Shanghai, China. ^[4] Institute of Interdisciplinary Science, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China. ^[5] Department of Neurology & Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. wgneuron@hotmail.com. ^[6]

主题词 1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine);动物(Animals);疾病模型, 动物(Disease Models, Animal);多巴胺(Dopamine);基因敲低技术(Gene Knockdown Techniques);人类(Humans);移动(Locomotion);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);微RNAs(MicroRNAs);神经变性(Nerve Degeneration);神经毒素类(Neurotoxins);PC12细胞(PC12 Cells);帕金森病(Parkinson Disease);大鼠(Rats);黑质(Substantia Nigra);转染(Transfection)

DOI 10.1038/s41419-019-1809-5

PMID 31383850

发布时间 2021-01-10

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Cell death & disease

Cell death & disease

2019年10卷8期

589页

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2019年10卷8期

589页

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