换一批Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway.
第一作者：
Yayun,Liu
第一单位：
Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University, Wuhan 430062, China.
作者：
关键词
2-NBDG, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino)-2-deoxyglucoseALT, alanine aminotransferaseAST, aspartate aminotransferaseAcox, acyl-coenzyme A oxidase XAkt, serine–threonine protein kinaseCAT, catalaseCFLARCFLAR, caspase 8 and Fas-associated protein with death domain-like apoptosis regulatorCYP2E1, cytochrome P450 2E1CYP4A, cytochrome P450 4ACpt1α, carnitine palmitoyl transferase 1αFabp5, fatty acid-binding proteins 5GSH-Px, glutathione peroxidaseGpat, glycerol-3-phosphate acyltransferaseHE, hematoxylin–eosinHO-1, heme oxygenase 1IR, insulin resistanceIRS1, insulin receptor substrate 1JNK, c-Jun N-terminal kinaseLipid accumulationMAPK, mitogen-activated protein kinaseMCD, methionine- and choline-deficientMCS, methionine- and choline-sufficientMDA, malondialdehydeMT, Masson–TrichromeMttp, microsomal triglyceride transfer proteinNAFLD, non-alcoholic fatty liver diseaseNASHNASH, nonalcoholic steatohepatitisNF-κB, nuclear factor κBNRF2, nuclear factor erythroid 2-related factor 2OA, oleic acidORO, oil red OOxidation stressPA, palmitic acidPI3K, phosphatidylinositol 3-hydroxy kinasePnpla3, phospholipase domain containing 3Pparα, peroxisome proliferator activated receptor αSD, Sprague–DawleyScd-1, stearoyl-coenzyme A desaturase-1SilibininSrebp-1c, sterol regulatory element binding protein-1CTC, total cholesterolTG, triglyceridepIRS1, phosphorylation of insulin receptor substrate 1pJNK, phosphorylation of c-Jun N-terminal kinase
DOI
10.1016/j.apsb.2019.02.006
PMID
31384535
发布时间
2023-10-13
- 浏览1
Acta pharmaceutica Sinica. B
2019年9卷4期
745-757页
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