Functional analysis of natural PCSK9 mutants in modern and archaic humans.

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作者： Sepideh,Mikaeeli ^[1] ; Delia,Susan-Resiga ^[1] ; Emmanuelle,Girard ^[1] ; Ali,Ben Djoudi Ouadda ^[1] ; Robert,Day ^[2] ; Stefan,Prost ^[3] ; Nabil G,Seidah ^[1]

作者单位： Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Canada. ^[1] Department of Surgery/Urology Division, Faculté de Médecine et des Sciences de la Santé, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Canada. ^[2] LOEWE-Center for Translational Biodiversity Genomics, Senckenberg Nature Research Society, Frankfurt, Germany. ^[3]

关键词 LDL-cholesterol PCSK9 cell-based assays hypercholesterolemia loss-of-function mutations

主题词动物(Animals);结合部位(Binding Sites);DNA甲基化(DNA Methylation);人类(Humans);蛋白质结合(Protein Binding);受体, LDL(Receptors, LDL)

DOI 10.1111/febs.15036

PMID 31386798

发布时间 2020-10-15

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