Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum.

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第一作者： Michael A,Ghebre

第一单位： Institute for Lung Health NIHR Leicester Biomedical Research Centre Department of Respiratory Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, LE3 9QP, UK.

作者： Michael A,Ghebre ^[1] ; Pee Hwee,Pang ^[2] ; Dhananjay,Desai ^[1] ; Beverley,Hargadon ^[1] ; Chris,Newby ^[1] ; Joanne,Woods ^[3] ; Laura,Rapley ^[3] ; Suzanne E,Cohen ^[3] ; Athula,Herath ^[3] ; Erol A,Gaillard ^[1] ; Richard D,May ^[4] ; Chris E,Brightling ^[5]

作者单位： Institute for Lung Health NIHR Leicester Biomedical Research Centre Department of Respiratory Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, LE3 9QP, UK. ^[1] Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore. ^[2] MedImmune Ltd, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK. ^[3] MedImmune Ltd, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.;Present address: Camallergy, Cambridge Biomedical Campus, Cambridge, UK. ^[4] Institute for Lung Health NIHR Leicester Biomedical Research Centre Department of Respiratory Sciences, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, LE3 9QP, UK. ceb17@leicester.ac.uk. ^[5]

关键词 Asthma Biomarkers Cytokines Sputum