A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
作者:
主题词
别构调节(Allosteric Regulation);动物(Animals);抗凝药(Anticoagulants);血液凝固(Blood Coagulation);氯化物(Chlorides);疾病模型, 动物(Disease Models, Animal);因子Ⅺa(Factor XIa);女(雌)性(Female);正铁化合物(Ferric Compounds);出血(Hemorrhage);肝素(Heparin);人类(Humans);肌醇(Inositol);分子模拟(Molecular Mimicry);大鼠, Wistar(Rats, Wistar);危险性评估(Risk Assessment);硫酸盐类(Sulfates);血栓形成(Thrombosis)
DOI
10.1111/jth.14606
PMID
31397071
发布时间
2023-11-04
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Journal of thrombosis and haemostasis
2110-2122页
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