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Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study.

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第一作者： Xin,Niu

第一单位： Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.

作者： Xin,Niu ^[1] ; Laura M,Amendola ^[2] ; Ragan,Hart ^[2] ; Caroline S,Bennette ^[3] ; Patrick,Heagerty ^[4] ; Martha,Horike-Pyne ^[2] ; Susan B,Trinidad ^[5] ; Elisabeth A,Rosenthal ^[2] ; Bryan,Comstock ^[4] ; Chris,Nefcy ^[4] ; Fuki M,Hisama ^[2] ; Robin L,Bennett ^[2] ; William M,Grady ^[6] ; Carlos J,Gallego ^[7] ; Peter,Tarczy-Hornoch ^[8] ; Stephanie M,Fullerton ^[5] ; Wylie,Burke ^[5] ; Dean A,Regier ^[9] ; Michael O,Dorschner ^[10] ; Brian H,Shirts ^[11] ; Peggy D,Robertson ^[12] ; Deborah A,Nickerson ^[12] ; Donald L,Patrick ^[13] ; Gail P,Jarvik ^[14] ; David L,Veenstra ^[15]

作者单位： Department of Epidemiology, University of Washington, Seattle, WA 98195, USA. ^[1] Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA. ^[2] Flatiron Health, New York, NY 10010, USA. ^[3] Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. ^[4] Department of Bioethics and Humanities, University of Washington, Seattle, WA 98195, USA. ^[5] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98101, USA. ^[6] Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA; Comparative Health Outcomes, Economics and Policy Institute (CHOICE), University of Washington, Seattle, WA 98195, USA. ^[7] Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195, USA. ^[8] Canadian Centre for Applied Research in Cancer Control, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada. ^[9] Department of Pathology, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. ^[10] Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA. ^[11] Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. ^[12] Department of Health Services, University of Washington, Seattle, WA 98195, USA. ^[13] Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. ^[14] Comparative Health Outcomes, Economics and Policy Institute (CHOICE), University of Washington, Seattle, WA 98195, USA. Electronic address: veenstra@uw.edu. ^[15]

关键词 Clinical exome sequencing Comparative effectiveness Hereditary colorectal cancer/polyposis