Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis.

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第一作者： Ihsan Ekin,Demir

第一单位： Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; DKTK Munich site, Germany; SFB 1321, Germany. Electronic address: ekin.demir@tum.de.

作者： Ihsan Ekin,Demir ^[1] ; Tobias,Heinrich ^[2] ; Dominique G,Carty ^[2] ; Ömer Cemil,Saricaoglu ^[2] ; Sarah,Klauss ^[2] ; Steffen,Teller ^[2] ; Timo,Kehl ^[2] ; Carmen,Mota Reyes ^[2] ; Elke,Tieftrunk ^[2] ; Maria,Lazarou ^[3] ; Dorukhan H,Bahceci ^[4] ; Betül,Gökcek ^[4] ; Bahar E,Ucurum ^[4] ; Matthias,Maak ^[5] ; Kalliope N,Diakopoulos ^[6] ; Marina,Lesina ^[6] ; Michael,Schemann ^[3] ; Mert,Erkan ^[4] ; Achim,Krüger ^[7] ; Hana,Algül ^[6] ; Helmut,Friess ^[2] ; Güralp O,Ceyhan ^[8]

作者单位： Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; DKTK Munich site, Germany; SFB 1321, Germany. Electronic address: ekin.demir@tum.de. ^[1] Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ^[2] Human Biology, Technical University of Munich, Freising, Germany. ^[3] Department of Surgery, Koc University School of Medicine, Istanbul, Turkey. ^[4] Department of Surgery, University of Erlangen, Erlangen, Germany. ^[5] Department of Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ^[6] Institute for Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ^[7] Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; DKTK Munich site, Germany; SFB 1321, Germany. ^[8]

关键词 Atg5 Chronic pancreatitis Genetically engineered mice Neurology of the digestive tract Nitrergic Pain Pancreatic cancer nNOS

主题词成年人(Adult);动物(Animals);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);人类(Humans);免疫组织化学(Immunohistochemistry);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);分子靶向治疗(Molecular Targeted Therapy);神经痛(Neuralgia);一氧化氮合酶Ⅰ型(Nitric Oxide Synthase Type I);胰腺肿瘤(Pancreatic Neoplasms);胰腺炎, 慢性(Pancreatitis, Chronic)

DOI 10.1016/j.ebiom.2019.07.055

PMID 31401195

发布时间 2020-02-25

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EBioMedicine

2019年46卷

431-443页

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Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis.

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Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis.

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