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首页> Scientific reports> Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia.

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia.

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作者： Sachith,Mettananda ^[1] ; Nirmani,Yasara ^[2] ; Christopher A,Fisher ^[3] ; Stephen,Taylor ^[4] ; Richard,Gibbons ^[5] ; Doug,Higgs ^[4]

作者单位： Department of Paediatrics, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka. sachith.mettananda@kln.ac.lk. ^[1] Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK. sachith.mettananda@kln.ac.lk. ^[2] Department of Paediatrics, University of Kelaniya, Thalagolla Road, Ragama, 11010, Sri Lanka. ^[3] Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK. ^[4] Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. ^[5]

主题词细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);红系细胞(Erythroid Cells);胎血(Fetal Blood);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);人类(Humans);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);α珠蛋白类(alpha-Globins);β地中海贫血(beta-Thalassemia);γ珠蛋白类(gamma-Globins)

DOI 10.1038/s41598-019-48204-2

PMID 31406232

发布时间 2021-03-17

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Scientific reports

Scientific reports

2019年9卷1期

11649页

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