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首页> The Journal of clinical investigation> cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.

cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.

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作者： Zining,Wang ^[1] ; Jiemin,Chen ^[1] ; Jie,Hu ^[2] ; Hongxia,Zhang ^[1] ; Feifei,Xu ^[1] ; Wenzhuo,He ^[1] ; Xiaojuan,Wang ^[1] ; Mengyun,Li ^[1] ; Wenhua,Lu ^[3] ; Gucheng,Zeng ^[1] ; Penghui,Zhou ^[4] ; Peng,Huang ^[1] ; Siyu,Chen ^[1] ; Wende,Li ^[5] ; Liang-Ping,Xia ^[5] ; Xiaojun,Xia ^[1]

作者单位： State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. ^[1] Department of Medical Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. ^[2] College of Food Science and Engineering, Northwest A&F University, Yangling, China. ^[3] Department of Microbiology, Zhongshan School of Medicine, Key Laboratory for Tropical Diseases Control of the Ministry of Education, Sun Yat-sen University, Guangzhou, China. ^[4] Guangdong Laboratory Animals Monitoring Institute, Guangdong Key Laboratory of Laboratory Animals, Guangzhou, China. ^[5] Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. ^[6]

关键词 Antigen presentation Cancer immunotherapy Immunology Innate immunity Oncology

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);HEK293细胞(HEK293 Cells);人类(Humans);免疫, 细胞(Immunity, Cellular);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 基因敲除(Mice, Knockout);肿瘤蛋白质类(Neoplasm Proteins);肿瘤, 实验性(Neoplasms, Experimental);核苷酸基转移酶类(Nucleotidyltransferases);信号传导(Signal Transduction);T淋巴细胞(T-Lymphocytes);替尼泊甙(Teniposide);拓扑异构酶II抑制剂(Topoisomerase II Inhibitors);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1172/JCI127471

PMID 31408442

发布时间 2020-11-24

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The Journal of clinical investigation

The Journal of clinical investigation

2019年129卷11期

4850-4862页

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