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Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.

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第一作者： Xudong,Zhu

第一单位： From the Institute of Aging Research, Hangzhou Normal University School of Medicine, China (X.Z., H.W., T.L.).

作者： Xudong,Zhu ^[1] ; Weiyan,Shen ^[2] ; Ke,Yao ^[3] ; Hu,Wang ^[4] ; Bo,Liu ^[2] ; Tangliang,Li ^[1] ; Lijuan,Song ^[5] ; Daojun,Diao ^[2] ; Genxiang,Mao ^[6] ; Ping,Huang ^[7] ; Chengtao,Li ^[7] ; Hongbo,Zhang ^[8] ; Yejun,Zou ^[9] ; Yugang,Qiu ^[10] ; Yuzheng,Zhao ^[9] ; Wengong,Wang ^[11] ; Yi,Yang ^[9] ; Zeping,Hu ^[3] ; Johan,Auwerx ^[8] ; Joseph,Loscalzo ^[12] ; Yong,Zhou ^[13] ; Zhenyu,Ju ^[2]

作者单位： From the Institute of Aging Research, Hangzhou Normal University School of Medicine, China (X.Z., H.W., T.L.). ^[1] Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, China (W.S., H.W., B.L., D.D., Z.J.). ^[2] School of Pharmaceutical Sciences, Tsinghua University, Beijing, China (K.Y., Z.H.). ^[3] From the Institute of Aging Research, Hangzhou Normal University School of Medicine, China (X.Z., H.W., T.L.).;Key Laboratory of Regenerative Medicine of Ministry of Education, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Institute of Aging and Regenerative Medicine, Jinan University, China (W.S., H.W., B.L., D.D., Z.J.). ^[4] Department of Cardiology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China (L.S.). ^[5] Department of Geriatrics, Zhejiang Provincial Key Lab of Geriatrics, Geriatrics Research Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou, China (G.M.). ^[6] Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Institute of Forensic Sciences, Ministry of Justice, China (P.H., C.L.). ^[7] Laboratory for Integrative and Systems Physiology, Institute of Bioengineering, École Polytechnique Federale de Lausanne, Switzerland (H.Z., J.A.). ^[8] Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology (Y. Zou, Y. Zhao, Y.Y.). ^[9] School of Rehabilitation Medicine, Weifang Medical University, China (Y.Q.). ^[10] Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, China (W.W.). ^[11] Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.L.). ^[12] Beijing Sanbo Brain Hospital, Capital Medical University, China (Y. Zhou). ^[13]

关键词 aging autophagy heart mitochondria telomerase

医学主题词动物(Animals);细胞, 培养的(Cells, Cultured);女(雌)性(Female);内环境稳定(Homeostasis);长寿(Longevity);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);线粒体, 心脏(Mitochondria, Heart);肌细胞, 心脏(Myocytes, Cardiac);活性氧(Reactive Oxygen Species);末端转移酶端粒(Telomerase)

DOI 10.1161/CIRCRESAHA.119.315529

PMID 31412728

发布时间 2020-09-13

基金项目

P50 GM107618/GM/NIGMS NIH HHS/United States R01 HL061795/HL/NHLBI NIH HHS/United States R37 HL061795/HL/NHLBI NIH HHS/United States U01 HG007690/HG/NHGRI NIH HHS/United States

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