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The <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.

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第一作者: Yuetiva,Deming
第一单位: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.;Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
作者单位: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.;Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA. [1] Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. [2] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. [3] Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.;Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden. [4] Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.;Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.;Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK. [5] Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.;UK Dementia Research Institute at UCL, London, UK. [6] Department of Clinical Sciences Helsingborg, Lund University, Lund, Sweden. [7] Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. [8] Department of Anesthesiology, Sahlgrenska University Hospital, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden. [9] Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.;Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain. [10] IDIBAPS, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain. [11] IDIBAPS, Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain.;Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain. [12] Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.;Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.;German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. [13] Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. [14] Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;ISAR Bioscience GmbH, 2152 Planegg, Germany. [15] Institute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany. [16] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.;Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.;NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, MO 63110, USA. [17] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.;Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.;Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. [18] Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.;Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. [19] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. karchc@wustl.edu picciol@wustl.edu ccruchaga@wustl.edu.;Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.;NeuroGenomics and Informatics, Washington University School of Medicine, St. Louis, MO 63110, USA. [20] Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. karchc@wustl.edu picciol@wustl.edu ccruchaga@wustl.edu.;Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.;Brain and Mind Centre, University of Sydney, Sydney, NSW 2050, Australia. [21]
DOI 10.1126/scitranslmed.aau2291
PMID 31413141
发布时间 2024-09-22
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