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Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.

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第一作者： Yingying,Xu

第一单位： School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 230032, China.

作者： Yingying,Xu ^[1] ; Ziwen,Zhang ^[1] ; Xia,Jiang ^[1] ; Xing,Chen ^[2] ; Zhuo,Wang ^[1] ; Hamed,Alsulami ^[3] ; Hua-Li,Qin ^[4] ; Wenjian,Tang ^[5]

作者单位： School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 230032, China. ^[1] School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, China. ^[2] Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia. ^[3] School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, China. Electronic address: qinhuali@whut.edu.cn. ^[4] School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 230032, China. Electronic address: ahmupharm@126.com. ^[5]

关键词 Acetylcholinesterase Alzheimer's disease Butyrylcholinesterase Pyrazole SuFEx Sultone