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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

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第一作者: Brian W,Kunkle
第一单位: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu.
作者: Brian W,Kunkle [1] ; Benjamin,Grenier-Boley [2] ; Rebecca,Sims [3] ; Joshua C,Bis [4] ; Vincent,Damotte [2] ; Adam C,Naj [5] ; Anne,Boland [6] ; Maria,Vronskaya [7] ; Sven J,van der Lee [8] ; Alexandre,Amlie-Wolf [9] ; Céline,Bellenguez [2] ; Aura,Frizatti [7] ; Vincent,Chouraki [10] ; Eden R,Martin [11] ; Kristel,Sleegers [12] ; Nandini,Badarinarayan [7] ; Johanna,Jakobsdottir [13] ; Kara L,Hamilton-Nelson [11] ; Sonia,Moreno-Grau [14] ; Robert,Olaso [6] ; Rachel,Raybould [3] ; Yuning,Chen [15] ; Amanda B,Kuzma [9] ; Mikko,Hiltunen [16] ; Taniesha,Morgan [7] ; Shahzad,Ahmad [8] ; Badri N,Vardarajan [17] ; Jacques,Epelbaum [18] ; Per,Hoffmann [19] ; Merce,Boada [14] ; Gary W,Beecham [11] ; Jean-Guillaume,Garnier [6] ; Denise,Harold [20] ; Annette L,Fitzpatrick [21] ; Otto,Valladares [9] ; Marie-Laure,Moutet [6] ; Amy,Gerrish [22] ; Albert V,Smith [23] ; Liming,Qu [9] ; Delphine,Bacq [6] ; Nicola,Denning [3] ; Xueqiu,Jian [24] ; Yi,Zhao [9] ; Maria,Del Zompo [25] ; Nick C,Fox [26] ; Seung-Hoan,Choi [27] ; Ignacio,Mateo [28] ; Joseph T,Hughes [29] ; Hieab H,Adams [8] ; John,Malamon [9] ; Florentino,Sanchez-Garcia [30] ; Yogen,Patel [29] ; Jennifer A,Brody [4] ; Beth A,Dombroski [9] ; Maria Candida Deniz,Naranjo [30] ; Makrina,Daniilidou [31] ; Gudny,Eiriksdottir [13] ; Shubhabrata,Mukherjee [32] ; David,Wallon [33] ; James,Uphill [34] ; Thor,Aspelund [35] ; Laura B,Cantwell [9] ; Fabienne,Garzia [6] ; Daniela,Galimberti [36] ; Edith,Hofer [37] ; Mariusz,Butkiewicz [38] ; Bertrand,Fin [6] ; Elio,Scarpini [36] ; Chloe,Sarnowski [15] ; Will S,Bush [38] ; Stéphane,Meslage [6] ; Johannes,Kornhuber [39] ; Charles C,White [40] ; Yuenjoo,Song [38] ; Robert C,Barber [41] ; Sebastiaan,Engelborghs [42] ; Sabrina,Sordon [43] ; Dina,Voijnovic [8] ; Perrie M,Adams [44] ; Rik,Vandenberghe [45] ; Manuel,Mayhaus [43] ; L Adrienne,Cupples [46] ; Marilyn S,Albert [47] ; Peter P,De Deyn [42] ; Wei,Gu [43] ; Jayanadra J,Himali [48] ; Duane,Beekly [49] ; Alessio,Squassina [25] ; Annette M,Hartmann [50] ; Adelina,Orellana [27] ; Deborah,Blacker [51] ; Eloy,Rodriguez-Rodriguez [28] ; Simon,Lovestone [52] ; Melissa E,Garcia [53] ; Rachelle S,Doody [54] ; Carmen,Munoz-Fernadez [30] ; Rebecca,Sussams [55] ; Honghuang,Lin [56] ; Thomas J,Fairchild [57] ; Yolanda A,Benito [30] ; Clive,Holmes [55] ; Hata,Karamujić-Čomić [8] ; Matthew P,Frosch [58] ; Hakan,Thonberg [59] ; Wolfgang,Maier [60] ; Gennady,Roshchupkin [8] ; Bernardino,Ghetti [61] ; Vilmantas,Giedraitis [62] ; Amit,Kawalia [63] ; Shuo,Li [15] ; Ryan M,Huebinger [64] ; Lena,Kilander [62] ; Susanne,Moebus [65] ; Isabel,Hernández [14] ; M Ilyas,Kamboh [66] ; RoseMarie,Brundin [62] ; James,Turton [67] ; Qiong,Yang [15] ; Mindy J,Katz [68] ; Letizia,Concari [69] ; Jenny,Lord [67] ; Alexa S,Beiser [48] ; C Dirk,Keene [70] ; Seppo,Helisalmi [16] ; Iwona,Kloszewska [71] ; Walter A,Kukull [72] ; Anne Maria,Koivisto [16] ; Aoibhinn,Lynch [73] ; Lluís,Tarraga [14] ; Eric B,Larson [74] ; Annakaisa,Haapasalo [75] ; Brian,Lawlor [73] ; Thomas H,Mosley [76] ; Richard B,Lipton [68] ; Vincenzo,Solfrizzi [77] ; Michael,Gill [73] ; W T,Longstreth [78] ; Thomas J,Montine [70] ; Vincenza,Frisardi [79] ; Monica,Diez-Fairen [80] ; Fernando,Rivadeneira [81] ; Ronald C,Petersen [82] ; Vincent,Deramecourt [83] ; Ignacio,Alvarez [80] ; Francesca,Salani [84] ; Antonio,Ciaramella [84] ; Eric,Boerwinkle [85] ; Eric M,Reiman [86] ; Nathalie,Fievet [2] ; Jerome I,Rotter [87] ; Joan S,Reisch [88] ; Olivier,Hanon [89] ; Chiara,Cupidi [90] ; A G Andre,Uitterlinden [81] ; Donald R,Royall [91] ; Carole,Dufouil [92] ; Raffaele Giovanni,Maletta [90] ; Itziar,de Rojas [14] ; Mary,Sano [93] ; Alexis,Brice [94] ; Roberta,Cecchetti [95] ; Peter St,George-Hyslop [96] ; Karen,Ritchie [97] ; Magda,Tsolaki [31] ; Debby W,Tsuang [98] ; Bruno,Dubois [99] ; David,Craig [100] ; Chuang-Kuo,Wu [101] ; Hilkka,Soininen [16] ; Despoina,Avramidou [31] ; Roger L,Albin [102] ; Laura,Fratiglioni [103] ; Antonia,Germanou [31] ; Liana G,Apostolova [104] ; Lina,Keller [103] ; Maria,Koutroumani [31] ; Steven E,Arnold [105] ; Francesco,Panza [79] ; Olymbia,Gkatzima [31] ; Sanjay,Asthana [106] ; Didier,Hannequin [29] ; Patrice,Whitehead [11] ; Craig S,Atwood [107] ; Paolo,Caffarra [108] ; Harald,Hampel [109] ; Inés,Quintela [110] ; Ángel,Carracedo [110] ; Lars,Lannfelt [62] ; David C,Rubinsztein [111] ; Lisa L,Barnes [112] ; Florence,Pasquier [83] ; Lutz,Frölich [113] ; Sandra,Barral [17] ; Bernadette,McGuinness [100] ; Thomas G,Beach [114] ; Janet A,Johnston [100] ; James T,Becker [115] ; Peter,Passmore [100] ; Eileen H,Bigio [116] ; Jonathan M,Schott [22] ; Thomas D,Bird [117] ; Jason D,Warren [22] ; Bradley F,Boeve [82] ; Michelle K,Lupton [118] ; James D,Bowen [119] ; Petra,Proitsi [29] ; Adam,Boxer [120] ; John F,Powell [29] ; James R,Burke [121] ; John S K,Kauwe [122] ; Jeffrey M,Burns [123] ; Michelangelo,Mancuso [124] ; Joseph D,Buxbaum [125] ; Ubaldo,Bonuccelli [124] ; Nigel J,Cairns [126] ; Andrew,McQuillin [127] ; Chuanhai,Cao [128] ; Gill,Livingston [127] ; Chris S,Carlson [129] ; Nicholas J,Bass [127] ; Cynthia M,Carlsson [130] ; John,Hardy [131] ; Regina M,Carney [132] ; Jose,Bras [133] ; Minerva M,Carrasquillo [134] ; Rita,Guerreiro [133] ; Mariet,Allen [134] ; Helena C,Chui [135] ; Elizabeth,Fisher [136] ; Carlo,Masullo [137] ; Elizabeth A,Crocco [138] ; Charles,DeCarli [139] ; Gina,Bisceglio [134] ; Malcolm,Dick [140] ; Li,Ma [134] ; Ranjan,Duara [141] ; Neill R,Graff-Radford [134] ; Denis A,Evans [142] ; Angela,Hodges [143] ; Kelley M,Faber [144] ; Martin,Scherer [145] ; Kenneth B,Fallon [146] ; Matthias,Riemenschneider [43] ; David W,Fardo [147] ; Reinhard,Heun [148] ; Martin R,Farlow [149] ; Heike,Kölsch [148] ; Steven,Ferris [150] ; Markus,Leber [151] ; Tatiana M,Foroud [144] ; Isabella,Heuser [152] ; Douglas R,Galasko [153] ; Ina,Giegling [50] ; Marla,Gearing [154] ; Michael,Hüll [155] ; Daniel H,Geschwind [156] ; John R,Gilbert [11] ; John,Morris [157] ; Robert C,Green [158] ; Kevin,Mayo [159] ; John H,Growdon [160] ; Thomas,Feulner [43] ; Ronald L,Hamilton [161] ; Lindy E,Harrell [162] ; Dmitriy,Drichel [163] ; Lawrence S,Honig [164] ; Thomas D,Cushion [3] ; Matthew J,Huentelman [165] ; Paul,Hollingworth [7] ; Christine M,Hulette [166] ; Bradley T,Hyman [160] ; Rachel,Marshall [7] ; Gail P,Jarvik [167] ; Alun,Meggy [7] ; Erin,Abner [168] ; Georgina E,Menzies [3] ; Lee-Way,Jin [169] ; Ganna,Leonenko [7] ; Luis M,Real [169] ; Gyungah R,Jun [170] ; Clinton T,Baldwin [170] ; Detelina,Grozeva [7] ; Anna,Karydas [119] ; Giancarlo,Russo [171] ; Jeffrey A,Kaye [172] ; Ronald,Kim [173] ; Frank,Jessen [174] ; Neil W,Kowall [175] ; Bruno,Vellas [176] ; Joel H,Kramer [177] ; Emma,Vardy [178] ; Frank M,LaFerla [179] ; Karl-Heinz,Jöckel [65] ; James J,Lah [180] ; Martin,Dichgans [181] ; James B,Leverenz [182] ; David,Mann [183] ; Allan I,Levey [180] ; Stuart,Pickering-Brown [183] ; Andrew P,Lieberman [184] ; Norman,Klopp [185] ; Kathryn L,Lunetta [15] ; H-Erich,Wichmann [186] ; Constantine G,Lyketsos [187] ; Kevin,Morgan [188] ; Daniel C,Marson [162] ; Kristelle,Brown [67] ; Frank,Martiniuk [189] ; Christopher,Medway [67] ; Deborah C,Mash [190] ; Markus M,Nöthen [191] ; Eliezer,Masliah [192] ; Nigel M,Hooper [183] ; Wayne C,McCormick [32] ; Antonio,Daniele [193] ; Susan M,McCurry [194] ; Anthony,Bayer [195] ; Andrew N,McDavid [128] ; John,Gallacher [52] ; Ann C,McKee [175] ; Hendrik,van den Bussche [145] ; Marsel,Mesulam [196] ; Carol,Brayne [197] ; Bruce L,Miller [198] ; Steffi,Riedel-Heller [199] ; Carol A,Miller [200] ; Joshua W,Miller [201] ; Ammar,Al-Chalabi [202] ; John C,Morris [203] ; Christopher E,Shaw [204] ; Amanda J,Myers [138] ; Jens,Wiltfang [205] ; Sid,O'Bryant [41] ; John M,Olichney [139] ; Victoria,Alvarez [206] ; Joseph E,Parisi [207] ; Andrew B,Singleton [208] ; Henry L,Paulson [209] ; John,Collinge [34] ; William R,Perry [11] ; Simon,Mead [34] ; Elaine,Peskind [210] ; David H,Cribbs [211] ; Martin,Rossor [22] ; Aimee,Pierce [211] ; Natalie S,Ryan [34] ; Wayne W,Poon [140] ; Benedetta,Nacmias [212] ; Huntington,Potter [213] ; Sandro,Sorbi [214] ; Joseph F,Quinn [215] ; Eleonora,Sacchinelli [84] ; Ashok,Raj [128] ; Gianfranco,Spalletta [216] ; Murray,Raskind [210] ; Carlo,Caltagirone [217] ; Paola,Bossù [84] ; Maria Donata,Orfei [217] ; Barry,Reisberg [218] ; Robert,Clarke [219] ; Christiane,Reitz [220] ; A David,Smith [221] ; John M,Ringman [222] ; Donald,Warden [221] ; Erik D,Roberson [162] ; Gordon,Wilcock [221] ; Ekaterina,Rogaeva [223] ; Amalia Cecilia,Bruni [90] ; Howard J,Rosen [120] ; Maura,Gallo [90] ; Roger N,Rosenberg [224] ; Yoav,Ben-Shlomo [225] ; Mark A,Sager [226] ; Patrizia,Mecocci [95] ; Andrew J,Saykin [227] ; Pau,Pastor [80] ; Michael L,Cuccaro [11] ; Jeffery M,Vance [11] ; Julie A,Schneider [228] ; Lori S,Schneider [229] ; Susan,Slifer [11] ; William W,Seeley [120] ; Amanda G,Smith [128] ; Joshua A,Sonnen [70] ; Salvatore,Spina [61] ; Robert A,Stern [230] ; Russell H,Swerdlow [123] ; Mitchell,Tang [9] ; Rudolph E,Tanzi [160] ; John Q,Trojanowski [231] ; Juan C,Troncoso [232] ; Vivianna M,Van Deerlin [231] ; Linda J,Van Eldik [233] ; Harry V,Vinters [234] ; Jean Paul,Vonsattel [235] ; Sandra,Weintraub [236] ; Kathleen A,Welsh-Bohmer [237] ; Kirk C,Wilhelmsen [238] ; Jennifer,Williamson [164] ; Thomas S,Wingo [239] ; Randall L,Woltjer [240] ; Clinton B,Wright [241] ; Chang-En,Yu [32] ; Lei,Yu [242] ; Yasaman,Saba [243] ; Alzheimer Disease Genetics Consortium (ADGC) [244] ; European Alzheimer’s Disease Initiative (EADI) [245] ; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) [246] ; Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) [32] ; Alberto,Pilotto [242] ; Maria J,Bullido [247] ; Oliver,Peters [206] ; Paul K,Crane [95] ; David,Bennett [248] ; Paola,Bosco [249] ; Eliecer,Coto [250] ; Virginia,Boccardi [251] ; Phil L,De Jager [62] ; Alberto,Lleo [252] ; Nick,Warner [157] ; Oscar L,Lopez [59] ; Martin,Ingelsson [252] ; Panagiotis,Deloukas [24] ; Carlos,Cruchaga [253] ; Caroline,Graff [28] ; Rhian,Gwilliam [254] ; Myriam,Fornage [8] ; Alison M,Goate [255] ; Pascual,Sanchez-Juan [256] ; Patrick G,Kehoe [94] ; Najaf,Amin [254] ; Nilifur,Ertekin-Taner [53] ; Claudine,Berr [255] ; Stéphanie,Debette [257] ; Seth,Love [258] ; Lenore J,Launer [259] ; Steven G,Younkin [134] ; Jean-Francois,Dartigues [33] ; Chris,Corcoran [260] ; M Arfan,Ikram [258] ; Dennis W,Dickson [261] ; Gael,Nicolas [262] ; Dominique,Campion [249] ; JoAnn,Tschanz [258] ; Helena,Schmidt [263] ; Hakon,Hakonarson [264] ; Jordi,Clarimon [12] ; Ron,Munger [7] ; Reinhold,Schmidt [265] ; Lindsay A,Farrer [3] ; Christine,Van Broeckhoven [38] ; Michael C,O'Donovan [6] ; Anita L,DeStefano [7] ; Lesley,Jones [266] ; Jonathan L,Haines [17] ; Jean-Francois,Deleuze [3] ; Michael J,Owen [267] ; Vilmundur,Gudnason [268] ; Richard,Mayeux [9] ; Valentina,Escott-Price [14] ; Bruce M,Psaty [8] ; Alfredo,Ramirez [7] ; Li-San,Wang [269] ; Agustin,Ruiz [3] ; Cornelia M,van Duijn [270] ; Peter A,Holmans [9] ; Sudha,Seshadri [271] ; Julie,Williams [272] ; Phillippe,Amouyel ; Gerard D,Schellenberg ; Jean-Charles,Lambert ; Margaret A,Pericak-Vance
作者单位: John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu. [1] Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. [2] Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.;UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. [3] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [4] Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [5] Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France. [6] Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. [7] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. [8] Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [9] Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.;Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA. [10] John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. [11] Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.;Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. [12] Icelandic Heart Association, Kopavogur, Iceland. [13] Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. [14] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [15] Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Department of Neurology, Kuopio University Hospital, Kuopio, Finland. [16] Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Department of Neurology, Columbia University, New York, NY, USA. [17] UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France. [18] Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.;Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland. [19] School of Biotechnology, Dublin City University, Dublin, Ireland. [20] Department of Family Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA. [21] Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. [22] Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland. [23] Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA. [24] Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. [25] Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.;UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. [26] Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. [27] Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain. [28] Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. [29] Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain. [30] Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. [31] Department of Medicine, University of Washington, Seattle, WA, USA. [32] Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France. [33] Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK. [34] Icelandic Heart Association, Kopavogur, Iceland.;Centre for Public Health, University of Iceland, Reykjavik, Iceland. [35] Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.;University of Milan, Centro Dino Ferrari, Milan, Italy. [36] Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.;Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. [37] Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. [38] Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. [39] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. [40] Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. [41] Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.;Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium. [42] Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. [43] Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. [44] Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium. [45] Framingham Heart Study, Framingham, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [46] Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. [47] Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [48] National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA. [49] Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany. [50] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.;Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. [51] Department of Psychiatry, University of Oxford, Oxford, UK. [52] Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA. [53] Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA. [54] Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. [55] Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. [56] Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA. [57] C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA. [58] Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.;Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden. [59] German Center for Neurodegenerative Diseases, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. [60] Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA. [61] Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. [62] Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. [63] Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. [64] Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. [65] Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.;Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. [66] Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. [67] Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. [68] Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.;FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy. [69] Department of Pathology, University of Washington, Seattle, WA, USA. [70] Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland. [71] Department of Epidemiology, University of Washington, Seattle, WA, USA. [72] Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.;St. James's Hospital and Trinity College, Dublin, Ireland. [73] Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. [74] A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. [75] Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA. [76] Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy. [77] Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Neurology, University of Washington, Seattle, WA, USA. [78] Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy. [79] Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.;Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. [80] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.;Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands. [81] Department of Neurology, Mayo Clinic, Rochester, MN, USA. [82] CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France. [83] Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. [84] School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. [85] Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.;Arizona Alzheimer's Consortium, Phoenix, AZ, USA.;Banner Alzheimer's Institute, Phoenix, AZ, USA.;Department of Psychiatry, University of Arizona, Phoenix, AZ, USA. [86] Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. [87] Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. [88] University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France. [89] Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. [90] Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA. [91] University of Bordeaux, Inserm 1219, Bordeaux, France.;Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France. [92] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [93] Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.;AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France. [94] Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. [95] Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.;Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. [96] Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.;Montpellier University, Montpellier, France.;Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. [97] VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.;Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. [98] Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.;Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.;Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.;Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. [99] Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. [100] Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA. [101] Department of Neurology, University of Michigan, Ann Arbor, MI, USA.;Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.;Michigan Alzheimer Disease Center, Ann Arbor, MI, USA. [102] Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. [103] Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.;Department of Neurology, Indiana University, Indianapolis, IN, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA. [104] Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [105] Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.;Department of Medicine, University of Wisconsin, Madison, WI, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA. [106] Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.;Department of Neurology, Indiana University, Indianapolis, IN, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA. [107] Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.;Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. [108] AXA Research Fund & Sorbonne University Chair, Paris, France.;Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.;Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.;Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France. [109] Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain. [110] Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.;UK Dementia Research Institute, University of Cambridge, Cambridge, UK. [111] Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. [112] Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. [113] Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA. [114] Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [115] Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. [116] Department of Neurology, University of Washington, Seattle, WA, USA.;VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA. [117] Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. [118] Swedish Medical Center, Seattle, WA, USA. [119] Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. [120] Department of Neurology, Duke University, Durham, NC, USA. [121] Departments of Biology, Brigham Young University, Provo, UT, USA. [122] University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA. [123] Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy. [124] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [125] Department of Pathology and Immunology, Washington University, St. Louis, MO, USA. [126] Division of Psychiatry, University College London, London, UK. [127] USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA. [128] Department of Medicine, University of Wisconsin, Madison, WI, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA. [129] Fred Hutchinson Cancer Research Center, Seattle, WA, USA. [130] Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK. [131] Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA. [132] UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.;Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. [133] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. [134] Department of Neurology, University of Southern California, Los Angeles, CA, USA. [135] Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. [136] Department of Neurology, Catholic University of Rome, Rome, Italy. [137] Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. [138] Department of Neurology, University of California, Davis, Sacramento, CA, USA. [139] Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. [140] Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA. [141] Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. [142] Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. [143] Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. [144] Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. [145] Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. [146] Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA. [147] Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. [148] Department of Neurology, Indiana University, Indianapolis, IN, USA. [149] Department of Psychiatry, New York University, New York, NY, USA. [150] Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. [151] Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany. [152] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA. [153] Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.;Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA. [154] Department of Psychiatry, University of Freiburg, Freiburg, Germany. [155] Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA. [156] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.;Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA. [157] Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. [158] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.;Department of Neurology, Washington University, St. Louis, MO, USA.;Department of Genetics, Washington University, St. Louis, MO, USA. [159] Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. [160] Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA. [161] Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA. [162] Cologne Center for Genomics, University of Cologne, Cologne, Germany. [163] Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. [164] Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA. [165] Department of Pathology, Duke University, Durham, NC, USA. [166] Department of Genome Sciences, University of Washington, Seattle, WA, USA.;Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA. [167] Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA. [168] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain. [169] Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. [170] Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland. [171] Department of Neurology, Oregon Health &Science University, Portland, OR, USA.;Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA. [172] Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA. [173] German Center for Neurodegenerative Diseases, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. [174] Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA. [175] Inserm U558, University of Toulouse, Toulouse, France. [176] Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA. [177] Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK. [178] Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA. [179] Department of Neurology, Emory University, Atlanta, GA, USA. [180] Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.;German Center for Neurodegenerative Diseases, Munich, Germany. [181] Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA. [182] Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. [183] Department of Pathology, University of Michigan, Ann Arbor, MI, USA. [184] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany. [185] Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.;Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.;Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA. [186] Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA. [187] Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK. [188] Department of Medicine-Pulmonary, New York University, New York, NY, USA. [189] Department of Neurology, University of Miami, Miami, FL, USA. [190] Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. [191] Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.;Department of Pathology, University of California, San Diego, La Jolla, CA, USA. [192] Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy. [193] School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA. [194] Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK. [195] Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. [196] Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK. [197] Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA. [198] Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany. [199] Department of Pathology, University of Southern California, Los Angeles, CA, USA. [200] Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA. [201] Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK. [202] Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.;Department of Neurology, Washington University, St. Louis, MO, USA. [203] Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.;UK Dementia Research Institute, King's College London, London, UK. [204] Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.;German Center for Neurodegenerative Diseases, Goettingen, Germany.;IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal. [205] Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain. [206] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. [207] Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. [208] Department of Neurology, University of Michigan, Ann Arbor, MI, USA.;Michigan Alzheimer Disease Center, Ann Arbor, MI, USA. [209] Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. [210] Department of Neurology, University of California, Irvine, Irvine, CA, USA. [211] Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.;Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy. [212] Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA. [213] Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. [214] Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.;Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. [215] Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.;Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. [216] Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy. [217] Department of Psychiatry, New York University, New York, NY, USA.;Alzheimer's Disease Center, New York University, New York, NY, USA. [218] Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK. [219] Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Department of Epidemiology, Columbia University, New York, NY, USA. [220] Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK. [221] Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA. [222] Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. [223] Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA. [224] Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. [225] Department of Medicine, University of Wisconsin, Madison, WI, USA. [226] Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Neurology, Indiana University, Indianapolis, IN, USA. [227] Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.;Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA. [228] Department of Neurology, University of Southern California, Los Angeles, CA, USA.;Department of Psychiatry, University of Southern California, Los Angeles, CA, USA. [229] Department of Neurology, Boston University School of Medicine, Boston, MA, USA. [230] Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [231] Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. [232] Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA. [233] Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.;Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA. [234] Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA. [235] Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. [236] Department of Neurology, Duke University, Durham, NC, USA.;Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA. [237] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [238] Department of Neurology, Emory University, Atlanta, GA, USA.;Department of Human Genetics, Emory University, Atlanta, GA, USA. [239] Department of Pathology, Oregon Health & Science University, Portland, OR, USA. [240] National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. [241] Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. [242] Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria. [243] Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.;Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy. [244] Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.;IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain.;Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain. [245] Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.;German Center for Neurodegenerative Diseases, Berlin, Germany. [246] Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy. [247] Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. [248] Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.;Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain. [249] Somerset Partnership NHS Trust, Somerset, UK. [250] Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. [251] The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. [252] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [253] University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK. [254] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.;Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. [255] Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.;Montpellier University, Montpellier, France. [256] Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France. [257] Utah State University, Logan, UT, USA. [258] Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.;Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. [259] Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.;Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France. [260] Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.;Department of Neurology, Medical University Graz, Graz, Austria. [261] Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [262] Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria. [263] Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.;Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA.;Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. [264] Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [265] Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland. [266] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Health Services, University of Washington, Seattle, WA, USA.;Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA. [267] Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. [268] Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA. [269] Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.;Centre Hospitalier Universitaire de Lille, Lille, France. [270] Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.;Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr. [271] John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu. [272]
DOI 10.1038/s41588-019-0495-7
PMID 31417202
发布时间 2025-05-30
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