Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.
第一作者:
Brian W,Kunkle
第一单位:
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu.
作者:
Brian W,Kunkle [1]
;
Benjamin,Grenier-Boley [2]
;
Rebecca,Sims [3]
;
Joshua C,Bis [4]
;
Vincent,Damotte [2]
;
Adam C,Naj [5]
;
Anne,Boland [6]
;
Maria,Vronskaya [7]
;
Sven J,van der Lee [8]
;
Alexandre,Amlie-Wolf [9]
;
Céline,Bellenguez [2]
;
Aura,Frizatti [7]
;
Vincent,Chouraki [10]
;
Eden R,Martin [11]
;
Kristel,Sleegers [12]
;
Nandini,Badarinarayan [7]
;
Johanna,Jakobsdottir [13]
;
Kara L,Hamilton-Nelson [11]
;
Sonia,Moreno-Grau [14]
;
Robert,Olaso [6]
;
Rachel,Raybould [3]
;
Yuning,Chen [15]
;
Amanda B,Kuzma [9]
;
Mikko,Hiltunen [16]
;
Taniesha,Morgan [7]
;
Shahzad,Ahmad [8]
;
Badri N,Vardarajan [17]
;
Jacques,Epelbaum [18]
;
Per,Hoffmann [19]
;
Merce,Boada [14]
;
Gary W,Beecham [11]
;
Jean-Guillaume,Garnier [6]
;
Denise,Harold [20]
;
Annette L,Fitzpatrick [21]
;
Otto,Valladares [9]
;
Marie-Laure,Moutet [6]
;
Amy,Gerrish [22]
;
Albert V,Smith [23]
;
Liming,Qu [9]
;
Delphine,Bacq [6]
;
Nicola,Denning [3]
;
Xueqiu,Jian [24]
;
Yi,Zhao [9]
;
Maria,Del Zompo [25]
;
Nick C,Fox [26]
;
Seung-Hoan,Choi [27]
;
Ignacio,Mateo [28]
;
Joseph T,Hughes [29]
;
Hieab H,Adams [8]
;
John,Malamon [9]
;
Florentino,Sanchez-Garcia [30]
;
Yogen,Patel [29]
;
Jennifer A,Brody [4]
;
Beth A,Dombroski [9]
;
Maria Candida Deniz,Naranjo [30]
;
Makrina,Daniilidou [31]
;
Gudny,Eiriksdottir [13]
;
Shubhabrata,Mukherjee [32]
;
David,Wallon [33]
;
James,Uphill [34]
;
Thor,Aspelund [35]
;
Laura B,Cantwell [9]
;
Fabienne,Garzia [6]
;
Daniela,Galimberti [36]
;
Edith,Hofer [37]
;
Mariusz,Butkiewicz [38]
;
Bertrand,Fin [6]
;
Elio,Scarpini [36]
;
Chloe,Sarnowski [15]
;
Will S,Bush [38]
;
Stéphane,Meslage [6]
;
Johannes,Kornhuber [39]
;
Charles C,White [40]
;
Yuenjoo,Song [38]
;
Robert C,Barber [41]
;
Sebastiaan,Engelborghs [42]
;
Sabrina,Sordon [43]
;
Dina,Voijnovic [8]
;
Perrie M,Adams [44]
;
Rik,Vandenberghe [45]
;
Manuel,Mayhaus [43]
;
L Adrienne,Cupples [46]
;
Marilyn S,Albert [47]
;
Peter P,De Deyn [42]
;
Wei,Gu [43]
;
Jayanadra J,Himali [48]
;
Duane,Beekly [49]
;
Alessio,Squassina [25]
;
Annette M,Hartmann [50]
;
Adelina,Orellana [27]
;
Deborah,Blacker [51]
;
Eloy,Rodriguez-Rodriguez [28]
;
Simon,Lovestone [52]
;
Melissa E,Garcia [53]
;
Rachelle S,Doody [54]
;
Carmen,Munoz-Fernadez [30]
;
Rebecca,Sussams [55]
;
Honghuang,Lin [56]
;
Thomas J,Fairchild [57]
;
Yolanda A,Benito [30]
;
Clive,Holmes [55]
;
Hata,Karamujić-Čomić [8]
;
Matthew P,Frosch [58]
;
Hakan,Thonberg [59]
;
Wolfgang,Maier [60]
;
Gennady,Roshchupkin [8]
;
Bernardino,Ghetti [61]
;
Vilmantas,Giedraitis [62]
;
Amit,Kawalia [63]
;
Shuo,Li [15]
;
Ryan M,Huebinger [64]
;
Lena,Kilander [62]
;
Susanne,Moebus [65]
;
Isabel,Hernández [14]
;
M Ilyas,Kamboh [66]
;
RoseMarie,Brundin [62]
;
James,Turton [67]
;
Qiong,Yang [15]
;
Mindy J,Katz [68]
;
Letizia,Concari [69]
;
Jenny,Lord [67]
;
Alexa S,Beiser [48]
;
C Dirk,Keene [70]
;
Seppo,Helisalmi [16]
;
Iwona,Kloszewska [71]
;
Walter A,Kukull [72]
;
Anne Maria,Koivisto [16]
;
Aoibhinn,Lynch [73]
;
Lluís,Tarraga [14]
;
Eric B,Larson [74]
;
Annakaisa,Haapasalo [75]
;
Brian,Lawlor [73]
;
Thomas H,Mosley [76]
;
Richard B,Lipton [68]
;
Vincenzo,Solfrizzi [77]
;
Michael,Gill [73]
;
W T,Longstreth [78]
;
Thomas J,Montine [70]
;
Vincenza,Frisardi [79]
;
Monica,Diez-Fairen [80]
;
Fernando,Rivadeneira [81]
;
Ronald C,Petersen [82]
;
Vincent,Deramecourt [83]
;
Ignacio,Alvarez [80]
;
Francesca,Salani [84]
;
Antonio,Ciaramella [84]
;
Eric,Boerwinkle [85]
;
Eric M,Reiman [86]
;
Nathalie,Fievet [2]
;
Jerome I,Rotter [87]
;
Joan S,Reisch [88]
;
Olivier,Hanon [89]
;
Chiara,Cupidi [90]
;
A G Andre,Uitterlinden [81]
;
Donald R,Royall [91]
;
Carole,Dufouil [92]
;
Raffaele Giovanni,Maletta [90]
;
Itziar,de Rojas [14]
;
Mary,Sano [93]
;
Alexis,Brice [94]
;
Roberta,Cecchetti [95]
;
Peter St,George-Hyslop [96]
;
Karen,Ritchie [97]
;
Magda,Tsolaki [31]
;
Debby W,Tsuang [98]
;
Bruno,Dubois [99]
;
David,Craig [100]
;
Chuang-Kuo,Wu [101]
;
Hilkka,Soininen [16]
;
Despoina,Avramidou [31]
;
Roger L,Albin [102]
;
Laura,Fratiglioni [103]
;
Antonia,Germanou [31]
;
Liana G,Apostolova [104]
;
Lina,Keller [103]
;
Maria,Koutroumani [31]
;
Steven E,Arnold [105]
;
Francesco,Panza [79]
;
Olymbia,Gkatzima [31]
;
Sanjay,Asthana [106]
;
Didier,Hannequin [29]
;
Patrice,Whitehead [11]
;
Craig S,Atwood [107]
;
Paolo,Caffarra [108]
;
Harald,Hampel [109]
;
Inés,Quintela [110]
;
Ángel,Carracedo [110]
;
Lars,Lannfelt [62]
;
David C,Rubinsztein [111]
;
Lisa L,Barnes [112]
;
Florence,Pasquier [83]
;
Lutz,Frölich [113]
;
Sandra,Barral [17]
;
Bernadette,McGuinness [100]
;
Thomas G,Beach [114]
;
Janet A,Johnston [100]
;
James T,Becker [115]
;
Peter,Passmore [100]
;
Eileen H,Bigio [116]
;
Jonathan M,Schott [22]
;
Thomas D,Bird [117]
;
Jason D,Warren [22]
;
Bradley F,Boeve [82]
;
Michelle K,Lupton [118]
;
James D,Bowen [119]
;
Petra,Proitsi [29]
;
Adam,Boxer [120]
;
John F,Powell [29]
;
James R,Burke [121]
;
John S K,Kauwe [122]
;
Jeffrey M,Burns [123]
;
Michelangelo,Mancuso [124]
;
Joseph D,Buxbaum [125]
;
Ubaldo,Bonuccelli [124]
;
Nigel J,Cairns [126]
;
Andrew,McQuillin [127]
;
Chuanhai,Cao [128]
;
Gill,Livingston [127]
;
Chris S,Carlson [129]
;
Nicholas J,Bass [127]
;
Cynthia M,Carlsson [130]
;
John,Hardy [131]
;
Regina M,Carney [132]
;
Jose,Bras [133]
;
Minerva M,Carrasquillo [134]
;
Rita,Guerreiro [133]
;
Mariet,Allen [134]
;
Helena C,Chui [135]
;
Elizabeth,Fisher [136]
;
Carlo,Masullo [137]
;
Elizabeth A,Crocco [138]
;
Charles,DeCarli [139]
;
Gina,Bisceglio [134]
;
Malcolm,Dick [140]
;
Li,Ma [134]
;
Ranjan,Duara [141]
;
Neill R,Graff-Radford [134]
;
Denis A,Evans [142]
;
Angela,Hodges [143]
;
Kelley M,Faber [144]
;
Martin,Scherer [145]
;
Kenneth B,Fallon [146]
;
Matthias,Riemenschneider [43]
;
David W,Fardo [147]
;
Reinhard,Heun [148]
;
Martin R,Farlow [149]
;
Heike,Kölsch [148]
;
Steven,Ferris [150]
;
Markus,Leber [151]
;
Tatiana M,Foroud [144]
;
Isabella,Heuser [152]
;
Douglas R,Galasko [153]
;
Ina,Giegling [50]
;
Marla,Gearing [154]
;
Michael,Hüll [155]
;
Daniel H,Geschwind [156]
;
John R,Gilbert [11]
;
John,Morris [157]
;
Robert C,Green [158]
;
Kevin,Mayo [159]
;
John H,Growdon [160]
;
Thomas,Feulner [43]
;
Ronald L,Hamilton [161]
;
Lindy E,Harrell [162]
;
Dmitriy,Drichel [163]
;
Lawrence S,Honig [164]
;
Thomas D,Cushion [3]
;
Matthew J,Huentelman [165]
;
Paul,Hollingworth [7]
;
Christine M,Hulette [166]
;
Bradley T,Hyman [160]
;
Rachel,Marshall [7]
;
Gail P,Jarvik [167]
;
Alun,Meggy [7]
;
Erin,Abner [168]
;
Georgina E,Menzies [3]
;
Lee-Way,Jin [169]
;
Ganna,Leonenko [7]
;
Luis M,Real [169]
;
Gyungah R,Jun [170]
;
Clinton T,Baldwin [170]
;
Detelina,Grozeva [7]
;
Anna,Karydas [119]
;
Giancarlo,Russo [171]
;
Jeffrey A,Kaye [172]
;
Ronald,Kim [173]
;
Frank,Jessen [174]
;
Neil W,Kowall [175]
;
Bruno,Vellas [176]
;
Joel H,Kramer [177]
;
Emma,Vardy [178]
;
Frank M,LaFerla [179]
;
Karl-Heinz,Jöckel [65]
;
James J,Lah [180]
;
Martin,Dichgans [181]
;
James B,Leverenz [182]
;
David,Mann [183]
;
Allan I,Levey [180]
;
Stuart,Pickering-Brown [183]
;
Andrew P,Lieberman [184]
;
Norman,Klopp [185]
;
Kathryn L,Lunetta [15]
;
H-Erich,Wichmann [186]
;
Constantine G,Lyketsos [187]
;
Kevin,Morgan [188]
;
Daniel C,Marson [162]
;
Kristelle,Brown [67]
;
Frank,Martiniuk [189]
;
Christopher,Medway [67]
;
Deborah C,Mash [190]
;
Markus M,Nöthen [191]
;
Eliezer,Masliah [192]
;
Nigel M,Hooper [183]
;
Wayne C,McCormick [32]
;
Antonio,Daniele [193]
;
Susan M,McCurry [194]
;
Anthony,Bayer [195]
;
Andrew N,McDavid [128]
;
John,Gallacher [52]
;
Ann C,McKee [175]
;
Hendrik,van den Bussche [145]
;
Marsel,Mesulam [196]
;
Carol,Brayne [197]
;
Bruce L,Miller [198]
;
Steffi,Riedel-Heller [199]
;
Carol A,Miller [200]
;
Joshua W,Miller [201]
;
Ammar,Al-Chalabi [202]
;
John C,Morris [203]
;
Christopher E,Shaw [204]
;
Amanda J,Myers [138]
;
Jens,Wiltfang [205]
;
Sid,O'Bryant [41]
;
John M,Olichney [139]
;
Victoria,Alvarez [206]
;
Joseph E,Parisi [207]
;
Andrew B,Singleton [208]
;
Henry L,Paulson [209]
;
John,Collinge [34]
;
William R,Perry [11]
;
Simon,Mead [34]
;
Elaine,Peskind [210]
;
David H,Cribbs [211]
;
Martin,Rossor [22]
;
Aimee,Pierce [211]
;
Natalie S,Ryan [34]
;
Wayne W,Poon [140]
;
Benedetta,Nacmias [212]
;
Huntington,Potter [213]
;
Sandro,Sorbi [214]
;
Joseph F,Quinn [215]
;
Eleonora,Sacchinelli [84]
;
Ashok,Raj [128]
;
Gianfranco,Spalletta [216]
;
Murray,Raskind [210]
;
Carlo,Caltagirone [217]
;
Paola,Bossù [84]
;
Maria Donata,Orfei [217]
;
Barry,Reisberg [218]
;
Robert,Clarke [219]
;
Christiane,Reitz [220]
;
A David,Smith [221]
;
John M,Ringman [222]
;
Donald,Warden [221]
;
Erik D,Roberson [162]
;
Gordon,Wilcock [221]
;
Ekaterina,Rogaeva [223]
;
Amalia Cecilia,Bruni [90]
;
Howard J,Rosen [120]
;
Maura,Gallo [90]
;
Roger N,Rosenberg [224]
;
Yoav,Ben-Shlomo [225]
;
Mark A,Sager [226]
;
Patrizia,Mecocci [95]
;
Andrew J,Saykin [227]
;
Pau,Pastor [80]
;
Michael L,Cuccaro [11]
;
Jeffery M,Vance [11]
;
Julie A,Schneider [228]
;
Lori S,Schneider [229]
;
Susan,Slifer [11]
;
William W,Seeley [120]
;
Amanda G,Smith [128]
;
Joshua A,Sonnen [70]
;
Salvatore,Spina [61]
;
Robert A,Stern [230]
;
Russell H,Swerdlow [123]
;
Mitchell,Tang [9]
;
Rudolph E,Tanzi [160]
;
John Q,Trojanowski [231]
;
Juan C,Troncoso [232]
;
Vivianna M,Van Deerlin [231]
;
Linda J,Van Eldik [233]
;
Harry V,Vinters [234]
;
Jean Paul,Vonsattel [235]
;
Sandra,Weintraub [236]
;
Kathleen A,Welsh-Bohmer [237]
;
Kirk C,Wilhelmsen [238]
;
Jennifer,Williamson [164]
;
Thomas S,Wingo [239]
;
Randall L,Woltjer [240]
;
Clinton B,Wright [241]
;
Chang-En,Yu [32]
;
Lei,Yu [242]
;
Yasaman,Saba [243]
;
Alzheimer Disease Genetics Consortium (ADGC) [244]
;
European Alzheimer’s Disease Initiative (EADI) [245]
;
Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) [246]
;
Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) [32]
;
Alberto,Pilotto [242]
;
Maria J,Bullido [247]
;
Oliver,Peters [206]
;
Paul K,Crane [95]
;
David,Bennett [248]
;
Paola,Bosco [249]
;
Eliecer,Coto [250]
;
Virginia,Boccardi [251]
;
Phil L,De Jager [62]
;
Alberto,Lleo [252]
;
Nick,Warner [157]
;
Oscar L,Lopez [59]
;
Martin,Ingelsson [252]
;
Panagiotis,Deloukas [24]
;
Carlos,Cruchaga [253]
;
Caroline,Graff [28]
;
Rhian,Gwilliam [254]
;
Myriam,Fornage [8]
;
Alison M,Goate [255]
;
Pascual,Sanchez-Juan [256]
;
Patrick G,Kehoe [94]
;
Najaf,Amin [254]
;
Nilifur,Ertekin-Taner [53]
;
Claudine,Berr [255]
;
Stéphanie,Debette [257]
;
Seth,Love [258]
;
Lenore J,Launer [259]
;
Steven G,Younkin [134]
;
Jean-Francois,Dartigues [33]
;
Chris,Corcoran [260]
;
M Arfan,Ikram [258]
;
Dennis W,Dickson [261]
;
Gael,Nicolas [262]
;
Dominique,Campion [249]
;
JoAnn,Tschanz [258]
;
Helena,Schmidt [263]
;
Hakon,Hakonarson [264]
;
Jordi,Clarimon [12]
;
Ron,Munger [7]
;
Reinhold,Schmidt [265]
;
Lindsay A,Farrer [3]
;
Christine,Van Broeckhoven [38]
;
Michael C,O'Donovan [6]
;
Anita L,DeStefano [7]
;
Lesley,Jones [266]
;
Jonathan L,Haines [17]
;
Jean-Francois,Deleuze [3]
;
Michael J,Owen [267]
;
Vilmundur,Gudnason [268]
;
Richard,Mayeux [9]
;
Valentina,Escott-Price [14]
;
Bruce M,Psaty [8]
;
Alfredo,Ramirez [7]
;
Li-San,Wang [269]
;
Agustin,Ruiz [3]
;
Cornelia M,van Duijn [270]
;
Peter A,Holmans [9]
;
Sudha,Seshadri [271]
;
Julie,Williams [272]
;
Phillippe,Amouyel ;
Gerard D,Schellenberg ;
Jean-Charles,Lambert ;
Margaret A,Pericak-Vance
作者单位:
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu.
[1]
Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.
[2]
Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.;UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK.
[3]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[4]
Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[5]
Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France.
[6]
Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
[7]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
[8]
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[9]
Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.;Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
[10]
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
[11]
Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium.;Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
[12]
Icelandic Heart Association, Kopavogur, Iceland.
[13]
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.
[14]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[15]
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.;Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
[16]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Department of Neurology, Columbia University, New York, NY, USA.
[17]
UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France.
[18]
Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.;Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland.
[19]
School of Biotechnology, Dublin City University, Dublin, Ireland.
[20]
Department of Family Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.
[21]
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
[22]
Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[23]
Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA.
[24]
Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
[25]
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.;UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
[26]
Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain.
[27]
Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain.
[28]
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[29]
Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
[30]
Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
[31]
Department of Medicine, University of Washington, Seattle, WA, USA.
[32]
Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.
[33]
Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK.
[34]
Icelandic Heart Association, Kopavogur, Iceland.;Centre for Public Health, University of Iceland, Reykjavik, Iceland.
[35]
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.;University of Milan, Centro Dino Ferrari, Milan, Italy.
[36]
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.;Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
[37]
Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
[38]
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
[39]
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
[40]
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
[41]
Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.;Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
[42]
Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
[43]
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[44]
Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium.
[45]
Framingham Heart Study, Framingham, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[46]
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
[47]
Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[48]
National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
[49]
Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
[50]
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.;Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
[51]
Department of Psychiatry, University of Oxford, Oxford, UK.
[52]
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
[53]
Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
[54]
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
[55]
Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
[56]
Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA.
[57]
C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA.
[58]
Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden.;Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden.
[59]
German Center for Neurodegenerative Diseases, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
[60]
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
[61]
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
[62]
Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
[63]
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[64]
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
[65]
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.;Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
[66]
Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
[67]
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
[68]
Section of Neuroscience, DIMEC-University of Parma, Parma, Italy.;FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy.
[69]
Department of Pathology, University of Washington, Seattle, WA, USA.
[70]
Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
[71]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[72]
Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland.;St. James's Hospital and Trinity College, Dublin, Ireland.
[73]
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
[74]
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
[75]
Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.
[76]
Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy.
[77]
Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Neurology, University of Washington, Seattle, WA, USA.
[78]
Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy.
[79]
Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.;Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain.
[80]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands.;Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
[81]
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
[82]
CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
[83]
Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
[84]
School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.;Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
[85]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.;Arizona Alzheimer's Consortium, Phoenix, AZ, USA.;Banner Alzheimer's Institute, Phoenix, AZ, USA.;Department of Psychiatry, University of Arizona, Phoenix, AZ, USA.
[86]
Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
[87]
Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[88]
University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France.
[89]
Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
[90]
Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA.
[91]
University of Bordeaux, Inserm 1219, Bordeaux, France.;Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France.
[92]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[93]
Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.;AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France.
[94]
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
[95]
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.;Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
[96]
Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.;Montpellier University, Montpellier, France.;Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
[97]
VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.;Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
[98]
Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France.;Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France.;Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France.;Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
[99]
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
[100]
Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA.
[101]
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.;Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.;Michigan Alzheimer Disease Center, Ann Arbor, MI, USA.
[102]
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
[103]
Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.;Department of Neurology, Indiana University, Indianapolis, IN, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA.
[104]
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[105]
Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.;Department of Medicine, University of Wisconsin, Madison, WI, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.
[106]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.;Department of Neurology, Indiana University, Indianapolis, IN, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA.
[107]
Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.;Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
[108]
AXA Research Fund & Sorbonne University Chair, Paris, France.;Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France.;Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France.;Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France.
[109]
Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain.
[110]
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.;UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
[111]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
[112]
Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
[113]
Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA.
[114]
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
[115]
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[116]
Department of Neurology, University of Washington, Seattle, WA, USA.;VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA.
[117]
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
[118]
Swedish Medical Center, Seattle, WA, USA.
[119]
Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
[120]
Department of Neurology, Duke University, Durham, NC, USA.
[121]
Departments of Biology, Brigham Young University, Provo, UT, USA.
[122]
University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.
[123]
Department of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
[124]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[125]
Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.
[126]
Division of Psychiatry, University College London, London, UK.
[127]
USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
[128]
Department of Medicine, University of Wisconsin, Madison, WI, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.
[129]
Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
[130]
Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
[131]
Mental Health & Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA.
[132]
UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.;Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
[133]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
[134]
Department of Neurology, University of Southern California, Los Angeles, CA, USA.
[135]
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
[136]
Department of Neurology, Catholic University of Rome, Rome, Italy.
[137]
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
[138]
Department of Neurology, University of California, Davis, Sacramento, CA, USA.
[139]
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
[140]
Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA.
[141]
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
[142]
Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[143]
Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
[144]
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
[145]
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
[146]
Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
[147]
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
[148]
Department of Neurology, Indiana University, Indianapolis, IN, USA.
[149]
Department of Psychiatry, New York University, New York, NY, USA.
[150]
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
[151]
Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
[152]
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
[153]
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.;Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA.
[154]
Department of Psychiatry, University of Freiburg, Freiburg, Germany.
[155]
Neurogenetics Program, University of California, Los Angeles, Los Angeles, CA, USA.
[156]
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.;Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA.
[157]
Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[158]
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.;Department of Neurology, Washington University, St. Louis, MO, USA.;Department of Genetics, Washington University, St. Louis, MO, USA.
[159]
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
[160]
Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, USA.
[161]
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
[162]
Cologne Center for Genomics, University of Cologne, Cologne, Germany.
[163]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
[164]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
[165]
Department of Pathology, Duke University, Durham, NC, USA.
[166]
Department of Genome Sciences, University of Washington, Seattle, WA, USA.;Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.
[167]
Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, KY, USA.
[168]
Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
[169]
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
[170]
Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland.
[171]
Department of Neurology, Oregon Health &Science University, Portland, OR, USA.;Department of Neurology, Portland Veterans Affairs Medical Center, Portland, OR, USA.
[172]
Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
[173]
German Center for Neurodegenerative Diseases, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
[174]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Pathology, Boston University School of Medicine, Boston University, Boston, MA, USA.
[175]
Inserm U558, University of Toulouse, Toulouse, France.
[176]
Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA.
[177]
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
[178]
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
[179]
Department of Neurology, Emory University, Atlanta, GA, USA.
[180]
Institute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.;German Center for Neurodegenerative Diseases, Munich, Germany.
[181]
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.
[182]
Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
[183]
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
[184]
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany.
[185]
Helmholtz Center Munich, Institute of Epidemiology, Neuherberg, Munich, Germany.;Ludwig-Maximilians University Chair of Epidemiology, Munich, Germany.;Joint Biobank Munich and KORA Biobank, Baltimore, MD, USA.
[186]
Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
[187]
Human Genetics, Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
[188]
Department of Medicine-Pulmonary, New York University, New York, NY, USA.
[189]
Department of Neurology, University of Miami, Miami, FL, USA.
[190]
Institute of Human Genetics, University of Bonn, Bonn, Germany.;Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
[191]
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.;Department of Pathology, University of California, San Diego, La Jolla, CA, USA.
[192]
Institute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
[193]
School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA.
[194]
Institute of Primary Care and Public Health, Cardiff University, University Hospital of Wales, Cardiff, UK.
[195]
Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[196]
Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
[197]
Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
[198]
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
[199]
Department of Pathology, University of Southern California, Los Angeles, CA, USA.
[200]
Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.
[201]
Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.
[202]
Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.;Department of Neurology, Washington University, St. Louis, MO, USA.
[203]
Institute of Psychiatry, Psychology and Neuroscienceó, King's College London, London, UK.;UK Dementia Research Institute, King's College London, London, UK.
[204]
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.;German Center for Neurodegenerative Diseases, Goettingen, Germany.;IBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal.
[205]
Molecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
[206]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[207]
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
[208]
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.;Michigan Alzheimer Disease Center, Ann Arbor, MI, USA.
[209]
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
[210]
Department of Neurology, University of California, Irvine, Irvine, CA, USA.
[211]
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.;Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy.
[212]
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
[213]
Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
[214]
Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.;Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
[215]
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.;Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
[216]
Laboratory of Neuropsychiatry, IRCCS Santa Lucia Foundation, Rome, Italy.
[217]
Department of Psychiatry, New York University, New York, NY, USA.;Alzheimer's Disease Center, New York University, New York, NY, USA.
[218]
Oxford Healthy Aging Project, Clinical Trial Service Unit, University of Oxford, Oxford, UK.
[219]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Department of Epidemiology, Columbia University, New York, NY, USA.
[220]
Oxford Project to Investigate Memory and Ageing, University of Oxford, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK.
[221]
Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, Los Angeles, CA, USA.
[222]
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
[223]
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[224]
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
[225]
Department of Medicine, University of Wisconsin, Madison, WI, USA.
[226]
Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.;Department of Neurology, Indiana University, Indianapolis, IN, USA.
[227]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.;Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA.
[228]
Department of Neurology, University of Southern California, Los Angeles, CA, USA.;Department of Psychiatry, University of Southern California, Los Angeles, CA, USA.
[229]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
[230]
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[231]
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
[232]
Sanders-Brown Center on Aging, Department of Neuroscience, University of Kentucky, Lexington, KY, USA.
[233]
Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.;Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
[234]
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, NY, USA.
[235]
Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[236]
Department of Neurology, Duke University, Durham, NC, USA.;Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
[237]
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
[238]
Department of Neurology, Emory University, Atlanta, GA, USA.;Department of Human Genetics, Emory University, Atlanta, GA, USA.
[239]
Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
[240]
National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
[241]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
[242]
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
[243]
Gerontology and Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.;Department Geriatric Care, Orthogeriatrics and Rehabilitation, Galliera Hospital, Genova, Italy.
[244]
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.;IdiPAZ, Instituto de Investigación Sanitaria la Paz, Madrid, Spain.;Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
[245]
Department of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.;German Center for Neurodegenerative Diseases, Berlin, Germany.
[246]
Instituto di Ricovero e Cura a Carattere Scientifico, Associazione Oasi Maria Santissima Srl, Troina, Italy.
[247]
Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
[248]
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.;Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University Barcelona, Barcelona, Spain.
[249]
Somerset Partnership NHS Trust, Somerset, UK.
[250]
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
[251]
The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
[252]
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[253]
University of Bristol Medical School, Learning & Research level 2, Southmead Hospital, Bristol, UK.
[254]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.;Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
[255]
Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France.;Montpellier University, Montpellier, France.
[256]
Memory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
[257]
Utah State University, Logan, UT, USA.
[258]
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.;Departments of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
[259]
Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France.;Department of Research Rouvray Psychiatric Hospital, Sotteville-lès-Rouen, France.
[260]
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.;Department of Neurology, Medical University Graz, Graz, Austria.
[261]
Center for Applied Genomics, Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[262]
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria.
[263]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.;Department of Ophthalmology, Boston University School of Medicine, Boston University, Boston, MA, USA.;Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
[264]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[265]
Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
[266]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.;Department of Health Services, University of Washington, Seattle, WA, USA.;Kaiser Permanente, Washington Health Research Institute, Seattle, WA, USA.
[267]
Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.;Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
[268]
Framingham Heart Study, Framingham, MA, USA.;Department of Neurology, Boston University School of Medicine, Boston, MA, USA.;Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.
[269]
Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.;Institut Pasteur de Lille, Lille, France.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France.;Centre Hospitalier Universitaire de Lille, Lille, France.
[270]
Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. jean-charles.lambert@pasteur-lille.fr.;Institut Pasteur de Lille, Lille, France. jean-charles.lambert@pasteur-lille.fr.;Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. jean-charles.lambert@pasteur-lille.fr.
[271]
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. mpericak@miami.edu.
[272]
DOI
10.1038/s41588-019-0495-7
PMID
31417202
发布时间
2025-05-30
- 浏览5
Nature genetics
Nature genetics
1423-1424页
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