An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation.
作者:
主题词
等位基因(Alleles);染色质(Chromatin);染色质免疫沉淀法(Chromatin Immunoprecipitation);染色体, 人, 7对(Chromosomes, Human, Pair 7);计算生物学(Computational Biology);增强子元件, 遗传学(Enhancer Elements, Genetic);基因表达调控(Gene Expression Regulation);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);干扰素调节因子类(Interferon Regulatory Factors);连锁不平衡(Linkage Disequilibrium);红斑狼疮, 系统性(Lupus Erythematosus, Systemic);多态性, 单核苷酸(Polymorphism, Single Nucleotide);启动区, 遗传(Promoter Regions, Genetic);数量性状基因座位(Quantitative Trait Loci);硬皮病, 系统性(Scleroderma, Systemic);β核胞浆转运蛋白类(beta Karyopherins)
DOI
10.1016/j.jid.2019.06.147
PMID
31421124
发布时间
2020-09-14
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The Journal of investigative dermatology
348-360.e11页
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