Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

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第一作者： Hannah T,Stuart

第一单位： Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.

作者： Hannah T,Stuart ^[1] ; Giuliano G,Stirparo ^[2] ; Tim,Lohoff ^[3] ; Lawrence E,Bates ^[1] ; Masaki,Kinoshita ^[2] ; Chee Y,Lim ^[4] ; Elsa J,Sousa ^[2] ; Katsiaryna,Maskalenka ^[1] ; Aliaksandra,Radzisheuskaya ^[1] ; Andrew A,Malcolm ^[2] ; Mariana R P,Alves ^[2] ; Rebecca L,Lloyd ^[1] ; Sonia,Nestorowa ^[4] ; Peter,Humphreys ^[2] ; William,Mansfield ^[2] ; Wolf,Reik ^[5] ; Paul,Bertone ^[2] ; Jennifer,Nichols ^[3] ; Berthold,Göttgens ^[4] ; José C R,Silva ^[6]

作者单位： Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK. ^[1] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. ^[2] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. ^[3] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Haematology and Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. ^[4] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Babraham Institute and Wellcome Sanger Institute, Cambridge, UK. ^[5] Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK. Electronic address: jcs64@cam.ac.uk. ^[6]

关键词 cell identity transitions pluripotency reprogramming signaling transcriptional networks