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首页> Molecular and cellular biology> PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.

PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.

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作者： Sang Hee,Min ^[1] ; Aae,Suzuki ^[2] ; Lehn,Weaver ^[3] ; Jessica,Guzman ^[4] ; Yutein,Chung ^[3] ; Huiyan,Jin ^[2] ; Francina,Gonzalez ^[2] ; Claire,Trasorras ^[2] ; Liang,Zhao ^[2] ; Lynn A,Spruce ^[3] ; Steven H,Seeholzer ^[4] ; Edward M,Behrens ^[4] ; Charles S,Abrams ^[4]

作者单位： Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA minsa@med.umich.edu. ^[1] Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA. ^[2] Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. ^[3] Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. ^[4] Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. ^[5]

关键词 PIKfyve lysosome homeostasis lysosomes macrophage macrophages phosphatidylinositol-3,5-bisphosphate

主题词动物(Animals);内颗粒(Endosomes);女(雌)性(Female);内环境稳定(Homeostasis);炎症(Inflammation);溶酶体(Lysosomes);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);髓系细胞(Myeloid Cells);吞噬体(Phagosomes);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);磷脂酰肌醇磷酸盐类(Phosphatidylinositol Phosphates);磷脂酰肌醇类(Phosphatidylinositols);蛋白质转运(Protein Transport)

DOI 10.1128/MCB.00158-19

PMID 31427458

发布时间 2024-04-21

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Molecular and cellular biology

Molecular and cellular biology

2019年39卷21期

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