换一批
换一批Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program.
第一作者：
Maxime,Janin
第一单位：
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain.
作者：
Maxime,Janin [1]
;
Vanessa,Ortiz-Barahona [1]
;
Manuel Castro,de Moura [1]
;
Anna,Martínez-Cardús [1]
;
Pere,Llinàs-Arias [1]
;
Marta,Soler [1]
;
Daphna,Nachmani [2]
;
Joffrey,Pelletier [3]
;
Ulrike,Schumann [4]
;
Maria E,Calleja-Cervantes [1]
;
Sebastian,Moran [1]
;
Sonia,Guil [1]
;
Alberto,Bueno-Costa [1]
;
David,Piñeyro [1]
;
Montserrat,Perez-Salvia [1]
;
Margalida,Rosselló-Tortella [1]
;
Laia,Piqué [1]
;
Joan J,Bech-Serra [5]
;
Carolina,De La Torre [5]
;
August,Vidal [6]
;
María,Martínez-Iniesta [7]
;
Juan F,Martín-Tejera [8]
;
Alberto,Villanueva [8]
;
Alexandra,Arias [8]
;
Isabel,Cuartas [9]
;
Ana M,Aransay [9]
;
Andres Morales,La Madrid [10]
;
Angel M,Carcaboso [11]
;
Vicente,Santa-Maria [12]
;
Jaume,Mora [13]
;
Agustin F,Fernandez [11]
;
Mario F,Fraga [12]
;
Iban,Aldecoa [11]
;
Leire,Pedrosa [14]
;
Francesc,Graus [15]
;
Noemi,Vidal [16]
;
Fina,Martínez-Soler [17]
;
Avelina,Tortosa [18]
;
Cristina,Carrato [6]
;
Carme,Balañá [19]
;
Matthew W,Boudreau [19]
;
Paul J,Hergenrother [20]
;
Peter,Kötter [21]
;
Karl-Dieter,Entian [22]
;
Jürgen,Hench [22]
;
Stephan,Frank [23]
;
Sheila,Mansouri [23]
;
Gelareh,Zadeh [24]
;
Pablo D,Dans [24]
;
Modesto,Orozco [25]
;
George,Thomas [25]
;
Sandra,Blanco [26]
;
Joan,Seoane [26]
;
Thomas,Preiss [27]
;
Pier Paolo,Pandolfi [3]
;
Manel,Esteller [28]
作者单位：
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain.
[1]
Department of Medicine and Pathology, Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
[2]
Molecular Mechanisms and Experimental Therapy in Oncology Program, Metabolism and Cancer Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain.
[3]
EMBL-Australia Collaborating Group, Department of Genome Sciences, The John Curtin School of Medical Research, The Australian National University, Garran Road, Acton, ACT, 2601, Australia.
[4]
Proteomics Unit, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain.
[5]
Department of Pathology, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain.
[6]
Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
[7]
Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), Oncobell Program, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain.
[8]
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
[9]
Centro de Investigación Bimédica en Red de Enfermedades hepáticas y Digestivas (CIBERehd), CIC bioGUNE, 801A Bizkaia Technology Park, 48160, Derio, Spain.
[10]
Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain.
[11]
Pediatric Neuro-Oncology Unit, Department of Pediatric Hematology and Oncology, Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain.
[12]
Preclinical Therapeutics and Drug Delivery Research Program, Fundacio Sant Joan de Deu, Barcelona, Catalonia, Spain.
[13]
Institute of Oncology of Asturias (IUOPA), Instituto de Investigación Sanitaria del Principado de Asturias (ISPA-FINBA), 33011, Oviedo, Spain.
[14]
Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo-Principado de Asturias, Oviedo, Spain.
[15]
Pathology-Brain Bank, Hospital Clínic de Barcelona-CDB-August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Catalonia, Spain.
[16]
Glioma and Neural Stem Cell Group and Translational Genomics and Targeted Therapeutics in Solid Tumors Team, IDIBAPS, Barcelona, Catalonia, Spain.
[17]
Clinical and Experimental Neuroimmunology, IDIBAPS, Barcelona, Catalonia, Spain.
[18]
Faculty of Medicine and Health Sciences-Bellvitge, Universitat de Barcelona, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain.
[19]
Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.
[20]
Catalan Institute of Oncology, Hospital Germans Trias i Pujol, 08916, Badalona, Barcelona, Catalonia, Spain.
[21]
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
[22]
Institute for Molecular Biosciences, Goethe University, Frankfurt, Germany.
[23]
Division of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, 4031, Basel, Switzerland.
[24]
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.
[25]
Joint IRB-BSC Program on Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Catalonia, Spain.
[26]
Department of Biochemistry and Biomedicine, University of Barcelona, 08028, Barcelona, Spain.
[27]
Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain.
[28]
Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati Medical School, Cincinnati, OH, 45267-0508, USA.
[29]
CIC bioGUNE, 801A Bizkaia Technology Park, 48160, Derio, Spain.
[30]
Molecular Mechanisms Program, Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, 37007, Salamanca, Spain.
[31]
Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
[32]
Victor Chang Cardiac Research Institute, Darlinghurst (Sydney), NSW, 2010, Australia.
[33]
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.
[34]
Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain. mesteller@carrerasresearch.org.
[35]
Department of Biochemistry and Biomedicine, University of Barcelona, 08028, Barcelona, Spain. mesteller@carrerasresearch.org.
[36]
Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.
[37]
Josep Carreras Leukaemia Research Institute (IJC), Ctra de Can Ruti, Camí de les Escoles s/n, 08916, Badalona, Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.
[38]
主题词
动物(Animals);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);神经胶质瘤(Glioma);人类(Humans);甲基转移酶类(Methyltransferases);小鼠, 裸(Mice, Nude);肌蛋白质类(Muscle Proteins);肿瘤移植(Neoplasm Transplantation);蛋白质生物合成(Protein Biosynthesis);RNA, 核糖体, 28S(RNA, Ribosomal, 28S);核糖体(Ribosomes)
DOI
10.1007/s00401-019-02062-4
PMID
31428936
发布时间
2021-09-01
- 浏览5
Acta neuropathologica
Acta neuropathologica
1053-1074页
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