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Imatinib-loaded gold nanoparticles inhibit proliferation of fibroblasts and macrophages from systemic sclerosis patients and ameliorate experimental bleomycin-induced lung fibrosis.

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第一作者： Veronica,Codullo

第一单位： Rheumatology service, Cochin Hospital, 75014 Paris, France; Unit of Rheumatology, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.

作者： Veronica,Codullo ^[1] ; Emanuela,Cova ^[2] ; Laura,Pandolfi ^[2] ; Silvia,Breda ^[3] ; Monica,Morosini ^[2] ; Vanessa,Frangipane ^[2] ; Manuela,Malatesta ^[4] ; Laura,Calderan ^[4] ; Maddalena,Cagnone ^[5] ; Chiara,Pacini ^[6] ; Lorenzo,Cavagna ^[7] ; Helios,Recalde ^[2] ; Jörg H W,Distler ^[8] ; Marco,Giustra ^[6] ; Davide,Prosperi ^[9] ; Miriam,Colombo ^[10] ; Federica,Meloni ^[11] ; Carlomaurizio,Montecucco ^[12]

作者单位： Rheumatology service, Cochin Hospital, 75014 Paris, France; Unit of Rheumatology, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy. ^[1] Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy. ^[2] Unit of Rheumatology, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy. ^[3] Department of Neurosciences, Biomedicine and Movement sciences, University of Verona, 37100 Verona, Italy. ^[4] Department of Molecular Medicine, Biochemistry Unit, University of Pavia, 27100 Pavia, Italy. ^[5] Department of Biotechnology and Bioscience, University of Milano-Bicocca, 20100 Milan, Italy. ^[6] Unit of Rheumatology, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy; Department of Internal Medicine, University of Pavia, section of Rheumatology, 27100 Pavia, Italy. ^[7] Department of Internal Medicine, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), University Hospital Erlangen, 91050 Erlangen, Germany. ^[8] Department of Biotechnology and Bioscience, University of Milano-Bicocca, 20100 Milan, Italy; Laboratory of Nanotechnology, ICS Maugeri, 27100 Pavia, Italy. ^[9] Department of Biotechnology and Bioscience, University of Milano-Bicocca, 20100 Milan, Italy. Electronic address: miriam.colombo@unimib.it. ^[10] Unit of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy; Department of Internal Medicine, University of Pavia, Section of Pneumology, 27100 Pavia, Italy. ^[11] Unit of Rheumatology, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy; Department of Internal Medicine, University of Pavia, section of Rheumatology, 27100 Pavia, Italy; Rheumatology service, Cochin Hospital, 75014 Paris, France. ^[12]

关键词 Gold nanoparticles Imatinib Inhalatory delivery Interstitial lung fibrosis Systemic sclerosis