换一批
换一批A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals.
作者：
Joris,Deelen [1]
;
Johannes,Kettunen [2]
;
Krista,Fischer [3]
;
Ashley,van der Spek [4]
;
Stella,Trompet [5]
;
Gabi,Kastenmüller [6]
;
Andy,Boyd [7]
;
Jonas,Zierer [8]
;
Erik B,van den Akker [9]
;
Mika,Ala-Korpela [10]
;
Najaf,Amin [11]
;
Ayse,Demirkan [12]
;
Mohsen,Ghanbari [9]
;
Diana,van Heemst [11]
;
M Arfan,Ikram [13]
;
Jan Bert,van Klinken [14]
;
Simon P,Mooijaart [15]
;
Annette,Peters [4]
;
Veikko,Salomaa [16]
;
Naveed,Sattar [17]
;
Tim D,Spector [18]
;
Henning,Tiemeier [19]
;
Aswin,Verhoeven [20]
;
Melanie,Waldenberger [6]
;
Peter,Würtz [21]
;
George,Davey Smith [22]
;
Andres,Metspalu [6]
;
Markus,Perola [23]
;
Cristina,Menni [7]
;
Johanna M,Geleijnse [6]
;
Fotios,Drenos [24]
;
Marian,Beekman [25]
;
J Wouter,Jukema [26]
;
Cornelia M,van Duijn [27]
;
P Eline,Slagboom [7]
作者单位：
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. Joris.Deelen@age.mpg.de.
[1]
Max Planck Institute for Biology of Ageing, PO Box 41 06 23, 50866, Cologne, Germany. Joris.Deelen@age.mpg.de.
[2]
National Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
[3]
Computational Medicine, Center for Life Course Health Research and Biocenter Oulu, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
[4]
The Estonian Genome Center, University of Tartu, Riia 23b, 51010, Tartu, Estonia.
[5]
Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
[6]
Department of Internal Medicine, section of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
[7]
Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
[8]
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.
[9]
German Center for Diabetes Research (DZD), Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.
[10]
Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Strand, London, WC2R 2LS, UK.
[11]
ALSPAC, Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
[12]
Novartis Institutes for BioMedical Research, Novartis Campus, Fabrikstrasse 2, 4056, Basel, Switzerland.
[13]
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
[14]
The Delft Bioinformatics Lab, Delft University of Technology, PO Box 5031, 2600 GA, Delft, The Netherlands.
[15]
Systems Epidemiology, Baker Heart and Diabetes Institute, PO Box 6492, Melbourne Victoria, 3004, Australia.
[16]
Population Health Science, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
[17]
MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
[18]
NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Yliopistonranta 1C, Kuopio, 70210, Finland.
[19]
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University, Melbourne, Victoria, 3800, Australia.
[20]
Section of Statistical Multi-omics, Department of Clinical and Experimental research, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
[21]
Department of Genetics, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.
[22]
Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, PO Box 91735-951, 9133913716, Mashhad, Iran.
[23]
Department of Radiology and Nuclear Medicine, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
[24]
Department of Neurology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
[25]
Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
[26]
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
[27]
Institute of Epidemiology II, Helmholtz Zentrum München, Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.
[28]
Institute of Cardiovascular and Medical Sciences, Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.
[29]
Department of Psychiatry, Erasmus University Medical Center-Sophia Children's Hospital, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
[30]
Center for Proteomics and Metabolomics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.
[31]
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Ingolstaedter Landstraße 1, 85764, Neuherberg, Germany.
[32]
Nightingale Health Ltd., Mannerheimintie 164a, 00300, Helsinki, Finland.
[33]
Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 23b - 134, 51010, Tartu, Estonia.
[34]
Institute for Molecular Medicine Finland, University of Helsinki, Tukholmankatu 8, 00290, Helsinki, Finland.
[35]
Clinical and Molecular Metabolism Research Program, Faculty of Medicine, University of Helsinki, PO Box 63, 00014, Helsinki, Finland.
[36]
Division of Human Nutrition, Wageningen University, PO Box 17, 6700 AA, Wageningen, The Netherlands.
[37]
Department of Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.
[38]
Leiden Academic Centre for Drug Research, Leiden University, PO box 9502, 2300 RA, Leiden, The Netherlands.
[39]
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. P.Slagboom@lumc.nl.
[40]
主题词
青少年(Adolescent);成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);女(雌)性(Female);随访研究(Follow-Up Studies);人类(Humans);男(雄)性(Male);代谢组(Metabolome);代谢组学(Metabolomics);中年人(Middle Aged);死亡率(Mortality);预后(Prognosis);危险性评估(Risk Assessment);危险因素(Risk Factors);存活率分析(Survival Analysis);青年人(Young Adult)
DOI
10.1038/s41467-019-11311-9
PMID
31431621
发布时间
2022-01-31
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Nature communications
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