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首页> International immunopharmacology> LDC000067 suppresses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo.

LDC000067 suppresses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo.

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作者： Song,Xue ^[1] ; Qing,Shao ^[2] ; Li-Bo,Zhu ^[2] ; Ya-Fei,Jiang ^[1] ; Cong,Wang ^[2] ; Bao,Xue ^[2] ; Hai-Ming,Lu ^[2] ; Wei-Lin,Sang ^[3] ; Jin-Zhong,Ma ^[4]

作者单位： Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China; Shanghai Bone Tumor Institution, Shanghai, 201620, China. ^[1] Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ^[2] Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: sang_weilin@163.com. ^[3] Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: majinzhong1963@sina.com. ^[4]

关键词 CDK9 LDC000067 LPS NF-κB Osteoclast Osteolysis Subchondral bone

主题词动物(Animals);骨髓细胞(Bone Marrow Cells);骨质吸收(Bone Resorption);骨和骨组织(Bone and Bones);牛(Cattle);细胞, 培养的(Cells, Cultured);细胞周期蛋白依赖激酶9(Cyclin-Dependent Kinase 9);脂多糖类(Lipopolysaccharides);巨噬细胞(Macrophages);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);破骨细胞(Osteoclasts);骨生成(Osteogenesis);嘧啶类(Pyrimidines);RANK配体(RANK Ligand);磺胺类(Sulfonamides)

DOI 10.1016/j.intimp.2019.105826

PMID 31437791

发布时间 2020-02-13

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