Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo.
第一作者:
Juliana G,Xande
第一单位:
Department of Cell and Developmental Biology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
作者:
主题词
腺病毒科(Adenoviridae);动物(Animals);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);女(雌)性(Female);基因, p53(Genes, p53);遗传载体(Genetic Vectors);HEK293细胞(HEK293 Cells);人类(Humans);肺肿瘤(Lung Neoplasms);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);转导, 遗传(Transduction, Genetic);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1038/s41434-019-0096-1
PMID
31439890
发布时间
2022-04-17
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Gene therapy
51-61页
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