Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription.

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作者： Ming,Kong ^[1] ; Xuyang,Chen ^[1] ; Fangqiao,Lv ^[2] ; Haozhen,Ren ^[3] ; Zhiwen,Fan ^[3] ; Hao,Qin ^[1] ; Liming,Yu ^[1] ; Xiaolei,Shi ^[4] ; Yong,Xu ^[5]

作者单位： Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. ^[1] Department of Cell Biology and the Municipal Laboratory of Liver Protection and Regulation of Regeneration, School of Basic Medical Sciences, Capital Medical University, Beijing, China. ^[2] Department of Hepato-biliary Surgery and Department of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. ^[3] Department of Hepato-biliary Surgery and Department of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: njsxl2000@163.com. ^[4] Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China; Institute of Biomedical Research, Liaocheng University, Liaocheng, China. Electronic address: yjxu@njmu.edu.cn. ^[5]

关键词 Hepatic stellate cell Liver fibrosis Neutrophil cytosolic factor Reactive oxygen species Serum response factor Transcriptional regulation

主题词动物(Animals);疾病易感性(Disease Susceptibility);后成说, 遗传(Epigenesis, Genetic);基因表达调控(Gene Expression Regulation);肝星状细胞(Hepatic Stellate Cells);肝硬化(Liver Cirrhosis);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);模型, 生物学(Models, Biological);活性氧(Reactive Oxygen Species);血清反应因子(Serum Response Factor);转录激活(Transcriptional Activation)

DOI 10.1016/j.redox.2019.101302

PMID 31442911

发布时间 2020-02-27

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Redox biology

2019年26卷

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Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription.

Redox biology

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Redox biology

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Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription.

Redox biology

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Redox biology

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