<i>Pax9</i> is required for cardiovascular development and interacts with <i>Tbx1</i> in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis.-论文-万方医学网

第一作者： Helen M,Phillips

第一单位： Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UK.

作者： Helen M,Phillips ^[1] ; Catherine A,Stothard ^[1] ; Wasay M,Shaikh Qureshi ^[1] ; Anastasia I,Kousa ^[2] ; J Alberto,Briones-Leon ^[1] ; Ramada R,Khasawneh ^[1] ; Chloe,O'Loughlin ^[1] ; Rachel,Sanders ^[1] ; Silvia,Mazzotta ^[1] ; Rebecca,Dodds ^[1] ; Kerstin,Seidel ^[1] ; Timothy,Bates ^[3] ; Mitsushiro,Nakatomi ^[1] ; Simon J,Cockell ^[4] ; Jürgen E,Schneider ^[5] ; Timothy J,Mohun ^[6] ; René,Maehr ^[7] ; Ralf,Kist ^[8] ; Heiko,Peters ^[1] ; Simon D,Bamforth ^[9]

作者单位： Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UK. ^[1] Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[2] School of Dental Sciences, Newcastle University, Newcastle-upon-Tyne NE2 4BW, UK. ^[3] Bioinformatics Support Unit, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK. ^[4] Biomedical Imaging, University of Leeds, Leeds LS2 9JT, UK. ^[5] The Francis Crick Institute, London NW1 1AT, UK. ^[6] Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01605, USA. ^[7] Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UK.;School of Dental Sciences, Newcastle University, Newcastle-upon-Tyne NE2 4BW, UK. ^[8] Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UK simon.bamforth@newcastle.ac.uk. ^[9]

医学主题词动物(Animals);动脉(Arteries);鳃区(Branchial Region);心血管系统(Cardiovascular System);细胞分化(Cell Differentiation);胚胎, 哺乳动物(Embryo, Mammalian);内胚层(Endoderm);基因缺失(Gene Deletion);基因调控网络(Gene Regulatory Networks);杂合子(Heterozygote);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 生物学(Models, Biological);形态发生(Morphogenesis);突变(Mutation);神经嵴(Neural Crest);PAX9转录因子(PAX9 Transcription Factor);咽(Pharynx);蛋白质结合(Protein Binding);信号传导(Signal Transduction);T盒域蛋白质类(T-Box Domain Proteins)

DOI 10.1242/dev.177618

PMID 31444215

发布时间 2025-05-30

基金项目

FS/08/016/24741/BHF_/British Heart Foundation/United Kingdom FS/16/8/31984/BHF_/British Heart Foundation/United Kingdom P30 CA008748/CA/NCI NIH HHS/United States PG/16/39/32115/BHF_/British Heart Foundation/United Kingdom

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<i>Pax9</i> is required for cardiovascular development and interacts with <i>Tbx1</i> in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis.

Development (Cambridge, England)

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<i>Pax9</i> is required for cardiovascular development and interacts with <i>Tbx1</i> in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis.

Development (Cambridge, England)

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同项目论文

Development (Cambridge, England)

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