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Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits.

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第一作者： Wen,Zhang

第一单位： Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.

作者： Wen,Zhang ^[1] ; Georgios,Voloudakis ^[2] ; Veera M,Rajagopal ^[3] ; Ben,Readhead ^[4] ; Joel T,Dudley ^[5] ; Eric E,Schadt ^[5] ; Johan L M,Björkegren ^[6] ; Yungil,Kim ^[1] ; John F,Fullard ^[1] ; Gabriel E,Hoffman ^[5] ; Panos,Roussos ^[7]

作者单位： Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. ^[1] Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[2] Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.;Department of Biomedicine, Aarhus University, 8000, Aarhus, Denmark.;The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University, 8000, Aarhus, Denmark.;Centre for Integrative Sequencing (iSEQ), Aarhus University, 8000, Aarhus, Denmark. ^[3] Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.;The Biodesign Institute, Arizona State University, Tempe, AZ, 85281, USA. ^[4] Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. ^[5] Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.;Clinical Gene Networks AB, 114 44, Stockholm, Sweden.;Vascular Biology Unit, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden.;Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, 50411, Tartu, Estonia. ^[6] Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. panagiotis.roussos@mssm.edu.;Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA. panagiotis.roussos@mssm.edu.;Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, 10468, NY, USA. panagiotis.roussos@mssm.edu. ^[7]

医学主题词动物(Animals);数据库, 遗传学(Databases, Genetic);表观基因组学(Epigenomics);基因表达谱(Gene Expression Profiling);基因多效性(Genetic Pleiotropy);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);小鼠(Mice);模型, 遗传学(Models, Genetic);数量性状基因座位(Quantitative Trait Loci);软件(Software)

DOI 10.1038/s41467-019-11874-7

PMID 31444360

发布时间 2021-01-10

基金项目

R01 MH109897/MH/NIMH NIH HHS/United States R01 AG050986/AG/NIA NIH HHS/United States I01 BX004189/BX/BLRD VA/United States I01 BX002395/BX/BLRD VA/United States P50 MH096890/MH/NIMH NIH HHS/United States S10 OD018522/OD/NIH HHS/United States R01 MH109677/MH/NIMH NIH HHS/United States

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