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首页> Journal of molecular and cellular cardiology> Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3.

Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3.

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作者： Liping,Meng ^[1] ; Hui,Lin ^[1] ; Jie,Zhang ^[2] ; Na,Lin ^[1] ; Zhenzhu,Sun ^[2] ; Feidan,Gao ^[1] ; Hangqi,Luo ^[1] ; Tingjuan,Ni ^[1] ; Wenqiang,Luo ^[1] ; Jufang,Chi ^[3] ; Hangyuan,Guo ^[4]

作者单位： Department of Cardiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China. ^[1] Department of Cardiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China; The First Clinical Medical College, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. ^[2] Department of Cardiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China. Electronic address: jf_chi@163.com. ^[3] Department of Cardiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing 312000, Zhejiang, China; The First Clinical Medical College, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China. Electronic address: ghangyuan@hotmail.com. ^[4]

关键词 Cardiotoxicity Doxorubicin NLR family pyrin domain containing 3 Pyroptosis TINCR

主题词乙酰化作用(Acetylation);动物(Animals);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);细胞, 培养的(Cells, Cultured);多柔比星(Doxorubicin);基因表达调控(Gene Expression Regulation);基因敲低技术(Gene Knockdown Techniques);肌细胞, 心脏(Myocytes, Cardiac);启动区, 遗传(Promoter Regions, Genetic);RNA稳定性(RNA Stability);RNA, 信使(RNA, Messenger);RNA结合蛋白质类(RNA-Binding Proteins);大鼠, Wistar(Rats, Wistar)

DOI 10.1016/j.yjmcc.2019.08.009

PMID 31445005

发布时间 2020-08-03

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Journal of molecular and cellular cardiology

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