Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment.

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第一作者： Jens,Schuster

第一单位： Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Biomedical Centre, Box 815, 751 08 Uppsala, Sweden. Electronic address: jens.schuster@igp.uu.se.

作者： Jens,Schuster ^[1] ; Loora,Laan ^[2] ; Joakim,Klar ^[2] ; Zhe,Jin ^[3] ; Mikael,Huss ^[4] ; Sergiy,Korol ^[3] ; Feria Hikmet,Noraddin ^[2] ; Maria,Sobol ^[2] ; Bryndis,Birnir ^[3] ; Niklas,Dahl ^[5]

作者单位： Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Biomedical Centre, Box 815, 751 08 Uppsala, Sweden. Electronic address: jens.schuster@igp.uu.se. ^[1] Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Biomedical Centre, Box 815, 751 08 Uppsala, Sweden. ^[2] Department of Neuroscience, Uppsala University, Uppsala, Sweden. ^[3] Wallenberg long-term Bioinformatics Support, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. ^[4] Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Biomedical Centre, Box 815, 751 08 Uppsala, Sweden. Electronic address: niklas.dahl@igp.uu.se. ^[5]

关键词 Chromatin architecture Dravet syndrome Na(v)1.1 Neural differentiation Neurodevelopment SCN1A iPSC