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Cellular pharmacokinetics and pharmacodynamics mechanisms of ginkgo diterpene lactone and its modulation of P-glycoprotein expression in human SH-SY5Y cells.

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第一作者： Jing-Ying,Liu

第一单位： China Pharmaceutical University, Nanjing, China.;Jiangsu Kanion Modern Chinese Medicine Institute, Nanjing, China.

作者： Jing-Ying,Liu ^[1] ; Ting,Geng ^[2] ; Kun,Duan ^[3] ; Xia,Gao ^[4] ; Chao-Jie,Huang ^[1] ; Jia-Jia,Wang ^[4] ; Wen-Zhe,Huang ^[2] ; Lou-Sheng,Huang ^[5] ; Zhen-Zhong,Wang ^[6] ; Wei,Xiao ^[6]

作者单位： China Pharmaceutical University, Nanjing, China.;Jiangsu Kanion Modern Chinese Medicine Institute, Nanjing, China. ^[1] Jiangsu Kanion Modern Chinese Medicine Institute, Nanjing, China.;State Key Laboratory of Pharmaceutical New-Tech for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, China.;Jiangsu Enterprise Academician Workstation, National Enterprise Technology Center, National Post-doctoral Research Workstation, Lianyungang, China. ^[2] Jiangsu Kanion Modern Chinese Medicine Institute, Nanjing, China.;State Key Laboratory of Pharmaceutical New-Tech for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, China.;School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China. ^[3] Jiangsu Kanion Modern Chinese Medicine Institute, Nanjing, China.;State Key Laboratory of Pharmaceutical New-Tech for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, China. ^[4] China Pharmaceutical University, Nanjing, China. ^[5] State Key Laboratory of Pharmaceutical New-Tech for Chinese Medicine, Jiangsu Kanion Pharmaceutical Co. Ltd, Lianyungang, China.;Jiangsu Enterprise Academician Workstation, National Enterprise Technology Center, National Post-doctoral Research Workstation, Lianyungang, China. ^[6]

关键词 P-glycoprotein cellular pharmacokinetics ginkgo diterpene lactones mitochondria membrane potential oxygen-glucose deprivation and reoxygenation phosphatidylserine subcellular distribution