Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker.-论文-万方医学网

作者： C L,Ursini ^[1] ; E,Omodeo Salè ^[2] ; A M,Fresegna ^[3] ; A,Ciervo ^[3] ; C,Jemos ^[2] ; R,Maiello ^[3] ; G,Buresti ^[3] ; C,Colosio ^[4] ; F M,Rubino ^[4] ; Stefan,Mandić-Rajčević ^[4] ; P,Chiarella ^[3] ; D,Carbonari ^[3] ; P,Delrio ^[5] ; P,Maiolino ^[5] ; P,Marchetti ^[6] ; R,Boccia ^[6] ; S,Iavicoli ^[3] ; D,Cavallo ^[3]

作者单位： Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL - Italian Workers' Compensation Authority, Rome, Italy. Electronic address: c.ursini@inail.it. ^[1] Division of Pharmacy, European Institute of Oncology, Milan, Italy. ^[2] Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL - Italian Workers' Compensation Authority, Rome, Italy. ^[3] Department of Health Sciences, University of Milan and Occupational Health Unit of the ASST Santi Paolo e Carlo-International centre for Rural Health, Milan, Italy. ^[4] Istituto Nazionale Tumori, Fondazione "G. Pascale", Naples, Italy. ^[5] Medical Oncology, Sant'Andrea Hospital, Sapienza University of Rome, Italy. ^[6]

主题词成年人(Adult);抗肿瘤药(Antineoplastic Agents);病例对照研究(Case-Control Studies);DNA糖基化酶类(DNA Glycosylases);脱氧胞苷(Deoxycytidine);环境监测(Environmental Monitoring);女(雌)性(Female);氟尿嘧啶(Fluorouracil);人类(Humans);意大利(Italy);男(雄)性(Male);微核, 染色体不完整(Micronuclei, Chromosome-Defective);微核试验(Micronucleus Tests);中年人(Middle Aged);口腔黏膜(Mouth Mucosa);护理人员, 医院(Nursing Staff, Hospital);职业暴露(Occupational Exposure);职业卫生(Occupational Health);多态现象, 遗传(Polymorphism, Genetic);危险性评估(Risk Assessment);危险因素(Risk Factors);尿分析(Urinalysis)

DOI 10.1016/j.toxlet.2019.08.022

PMID 31465813

发布时间 2022-12-07

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Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker.

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Antineoplastic drug occupational exposure: a new integrated approach to evaluate exposure and early genotoxic and cytotoxic effects by no-invasive Buccal Micronucleus Cytome Assay biomarker.

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