Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo.

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作者： Antonello,Pessi ^[1] ; Sandra L,Bixler ^[2] ; Veronica,Soloveva ^[2] ; Sheli,Radoshitzky ^[2] ; Cary,Retterer ^[3] ; Tara,Kenny ^[3] ; Rouzbeh,Zamani ^[3] ; Glenn,Gomba ^[3] ; Dima,Gharabeih ^[3] ; Jay,Wells ^[3] ; Kelly S,Wetzel ^[3] ; Travis K,Warren ^[2] ; Ginger,Donnelly ^[3] ; Sean A,Van Tongeren ^[3] ; Jesse,Steffens ^[3] ; Allen J,Duplantier ^[2] ; Christopher D,Kane ^[4] ; Pascale,Vicat ^[5] ; Valerie,Couturier ^[5] ; Kent E,Kester ^[6] ; John,Shiver ^[6] ; Kara,Carter ^[7] ; Sina,Bavari ^[8]

作者单位： PeptiPharma, Rome, Italy. ^[1] United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA. ^[2] United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA. ^[3] United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA. Electronic address: christopher.d.kane.civ@mail.mil. ^[4] Sanofi, Paris, France. ^[5] Sanofi Pasteur, Swiftwater, PA, USA. ^[6] Sanofi, Cambridge, MA, USA. ^[7] United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA. Electronic address: sina.bavari.civ@mail.mil. ^[8]

关键词 Cholesterol Ebola virus Peptides Rodents Therapeutic