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首页> European journal of medicinal chemistry> The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities.

The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities.

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作者： Ganesan,Rajasekaran ^[1] ; S Dinesh,Kumar ^[1] ; Sungtae,Yang ^[2] ; Song Yub,Shin ^[3]

作者单位： Department of Biomedical Science, Graduate School, Chosun University, Gwangju, 61452, Republic of Korea. ^[1] Department of Biomedical Science, Graduate School, Chosun University, Gwangju, 61452, Republic of Korea; Department of Microbiology, School of Medicine, Chosun University, Gwangju, 61452, Republic of Korea. ^[2] Department of Biomedical Science, Graduate School, Chosun University, Gwangju, 61452, Republic of Korea; Department of Cellular & Molecular Medicine, School of Medicine, Chosun University, Gwangju, 61452, Republic of Korea. Electronic address: syshin@chosun.ac.kr. ^[3]

关键词 Anti-inflammatory activity Antimicrobial peptide Bacterial selectivity Cathelicidin Fowlicidin-1 Synergistic effect

主题词动物(Animals);抗菌药(Anti-Bacterial Agents);消炎药(Anti-Inflammatory Agents);内源性抗菌多肽类物质(Cathelicidins);细胞存活(Cell Survival);鸡(Chickens);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);红细胞(Erythrocytes);革兰氏阴性菌(Gram-Negative Bacteria);革兰氏阳性菌(Gram-Positive Bacteria);小鼠(Mice);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);肽碎片(Peptide Fragments);绵羊(Sheep);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2019.111623

PMID 31473417

发布时间 2020-01-02

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European journal of medicinal chemistry

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