换一批Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
第一作者：
Xueping,Liu
第一单位：
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
作者：
Xueping,Liu [1]
;
Dorte,Helenius [2]
;
Line,Skotte [1]
;
Robin N,Beaumont [3]
;
Matthias,Wielscher [4]
;
Frank,Geller [1]
;
Julius,Juodakis [5]
;
Anubha,Mahajan [6]
;
Jonathan P,Bradfield [7]
;
Frederick T J,Lin [8]
;
Suzanne,Vogelezang [9]
;
Mariona,Bustamante [10]
;
Tarunveer S,Ahluwalia [11]
;
Niina,Pitkänen [12]
;
Carol A,Wang [13]
;
Jonas,Bacelis [14]
;
Maria C,Borges [15]
;
Ge,Zhang [16]
;
Bruce A,Bedell [17]
;
Robert M,Rossi [18]
;
Kristin,Skogstrand [19]
;
Shouneng,Peng [20]
;
Wesley K,Thompson [2]
;
Vivek,Appadurai [2]
;
Debbie A,Lawlor [21]
;
Ilkka,Kalliala [22]
;
Christine,Power [23]
;
Mark I,McCarthy [24]
;
Heather A,Boyd [1]
;
Mary L,Marazita [25]
;
Hakon,Hakonarson [26]
;
M Geoffrey,Hayes [27]
;
Denise M,Scholtens [28]
;
Fernando,Rivadeneira [29]
;
Vincent W V,Jaddoe [9]
;
Rebecca K,Vinding [11]
;
Hans,Bisgaard [11]
;
Bridget A,Knight [30]
;
Katja,Pahkala [31]
;
Olli,Raitakari [32]
;
Øyvind,Helgeland [33]
;
Stefan,Johansson [34]
;
Pål R,Njølstad [35]
;
João,Fadista [36]
;
Andrew J,Schork [2]
;
Ron,Nudel [2]
;
Daniel E,Miller [37]
;
Xiaoting,Chen [37]
;
Matthew T,Weirauch [38]
;
Preben Bo,Mortensen [39]
;
Anders D,Børglum [40]
;
Merete,Nordentoft [41]
;
Ole,Mors [42]
;
Ke,Hao [20]
;
Kelli K,Ryckman [43]
;
David M,Hougaard [19]
;
Leah C,Kottyan [44]
;
Craig E,Pennell [13]
;
Leo-Pekka,Lyytikainen [45]
;
Klaus,Bønnelykke [11]
;
Martine,Vrijheid [10]
;
Janine F,Felix [9]
;
William L,Lowe [8]
;
Struan F A,Grant [26]
;
Elina,Hyppönen [46]
;
Bo,Jacobsson [47]
;
Marjo-Riitta,Jarvelin [48]
;
Louis J,Muglia [49]
;
Jeffrey C,Murray [17]
;
Rachel M,Freathy [50]
;
Thomas M,Werge [51]
;
Mads,Melbye [52]
;
Alfonso,Buil [2]
;
Bjarke,Feenstra [53]
作者单位：
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[1]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
[2]
Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
[3]
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
[4]
Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
[5]
Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
[6]
Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Quantinuum Research, LLC, San Diego, CA, USA.
[7]
Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[8]
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[9]
ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
[10]
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
[11]
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.
[12]
School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, NSW, Australia.
[13]
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
[14]
MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
[15]
Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
[16]
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
[17]
March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.;Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
[18]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Statens Serum Institut, Center for Neonatal Screening, Department for Congenital Disorders, Copenhagen, Denmark.
[19]
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.;Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
[20]
MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.;NIHR Bristol Biomedical Research Centre, Bristol, UK.
[21]
Department of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College, London, W12 0NN, UK.;Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu, 200029 HUS, Finland.
[22]
Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.
[23]
Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LJ, UK.;NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, OX3 7LJ, UK.
[24]
Center for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
[25]
Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[26]
Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Department of Anthropology, Northwestern University, Evanston, IL, USA.;Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[27]
Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[28]
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[29]
NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.
[30]
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.;Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Health and Physical Activity, University of Turku, 20520, Turku, Finland.
[31]
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland.;Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland.
[32]
K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.;Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.;Norwegian Institute of Public Health, Division of Health data and Digitalization, Department of Genetic Research and Bioinformatics, Oslo, Norway.
[33]
K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.;Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
[34]
K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.;Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
[35]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.;Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden.
[36]
Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
[37]
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.;Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.
[38]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.;iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
[39]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.;Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
[40]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[41]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
[42]
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.;Department of Epidemiology, University of Iowa, Iowa City, IA, USA.
[43]
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.;Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
[44]
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.;Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33014, Tampere, Finland.
[45]
Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London, London, UK.;Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, Australia.;South Australian Health and Medical Research Institute, Adelaide, Australia.
[46]
Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.;Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
[47]
Institute of Health Sciences, University of Oulu, Oulu, Finland.;Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, UK.
[48]
Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Department of Pediatrics, University of Iowa, Iowa City, IA, USA.;Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
[49]
Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK.;Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
[50]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[51]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
[52]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fee@ssi.dk.
[53]
医学主题词
染色体, 人, 2对(Chromosomes, Human, Pair 2);细胞因子类(Cytokines);女(雌)性(Female);胎儿(Fetus);基因组, 人(Genome, Human);全基因组关联研究(Genome-Wide Association Study);孕龄(Gestational Age);人类(Humans);婴儿, 新生(Infant, Newborn);多态性, 单核苷酸(Polymorphism, Single Nucleotide);妊娠(Pregnancy);早产(Premature Birth)
DOI
10.1038/s41467-019-11881-8
PMID
31477735
发布时间
2025-05-30
- 浏览3
Nature communications
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
