MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function.

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第一作者： Hyun Kyung,Ahn

第一单位： Cancer Research Institute, Seoul National University, Seoul 03080, Korea.

作者： Hyun Kyung,Ahn ^[1] ; Sehui,Kim ^[2] ; Dohee,Kwon ^[2] ; Jaemoon,Koh ^[3] ; Young A,Kim ^[4] ; Kwangsoo,Kim ^[5] ; Doo Hyun,Chung ^[3] ; Yoon Kyung,Jeon ^[6]

作者单位： Cancer Research Institute, Seoul National University, Seoul 03080, Korea. ^[1] Cancer Research Institute, Seoul National University, Seoul 03080, Korea.;Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea. ^[2] Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea.;Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea. ^[3] Department of Pathology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 03080, Korea. ^[4] Division of Clinical Bioinformatics, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea. ^[5] Cancer Research Institute, Seoul National University, Seoul 03080, Korea. ykjeon@snu.ac.kr.;Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Korea. ykjeon@snu.ac.kr. ^[6]

关键词 MET PD-1/PD-L1 pathway PD-L1 cancer immunotherapy co-inhibitory molecules co-stimulatory molecules immune checkpoint immune evasion lung cancer