The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation.
作者:
主题词
氨基酸序列(Amino Acid Sequence);CCAAT增强子结合蛋白类(CCAAT-Enhancer-Binding Proteins);DNA(DNA);DNA甲基化(DNA Methylation);HCT116细胞(HCT116 Cells);HEK293细胞(HEK293 Cells);人类(Humans);磷酸盐类(Phosphates);构效关系(Structure-Activity Relationship);泛素(Ubiquitin);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)
DOI
10.1074/jbc.RA119.010160
PMID
31481468
发布时间
2021-02-05
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The Journal of biological chemistry
15724-15732页
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